Carboprost | CAS# 35700-23-3 | PREGNANCY

MedKoo Cat#: 412320 | Name: Carboprost

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Carboprost a nonsteroidal abortifacient agent that is effective in both the first and second trimesters of PREGNANCY.

Chemical Structure

Carboprost

CAS#35700-23-3 (demethylated)

Theoretical Analysis

MedKoo Cat#: 412320

Name: Carboprost

CAS#: 35700-23-3 (demethylated)

Chemical Formula: C21H36O5

Exact Mass: 368.2563

Molecular Weight: 368.51

Elemental Analysis: C, 68.45; H, 9.85; O, 21.71

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 450.00	2 Weeks
10mg	USD 750.00	2 Weeks

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Related CAS #

35700-21-1 (methylated) 35700-23-3 (demethylated)

Synonym

Carboprost; U-32921; U32921; U 32921

IUPAC/Chemical Name

Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-15-methyl-, (5Z,9alpha,11alpha,13E,15S)-

InChi Key

DLJKPYFALUEJCK-IIELGFQLSA-N

InChi Code

InChI=1S/C21H36O5/c1-3-4-9-13-21(2,26)14-12-17-16(18(22)15-19(17)23)10-7-5-6-8-11-20(24)25/h5,7,12,14,16-19,22-23,26H,3-4,6,8-11,13,15H2,1-2H3,(H,24,25)/b7-5-,14-12+/t16-,17-,18+,19-,21+/m1/s1

SMILES Code

CCCCC[C@](C)(O)/C=C/[C@@H]1[C@H]([C@@H](O)C[C@H]1O)C/C=C\CCCC(O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 368.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Vallera C, Choi LO, Cha CM, Hong RW. Uterotonic Medications: Oxytocin, Methylergonovine, Carboprost, Misoprostol. Anesthesiol Clin. 2017 Jun;35(2):207-219. doi: 10.1016/j.anclin.2017.01.007. Epub 2017 Mar 30. PMID: 28526143. 2: Ling Z, Yao L, Cui Z, Lifan C. Effect of carboprost tromethamine in prevention of postpartum hemorrhage in cesarean section. Pak J Pharm Sci. 2018 Sep;31(5(Special)):2257-2262. PMID: 30463821. 3: Meng W, Li R, Zha N, E L. Efficacy and safety of motherwort injection add-on therapy to carboprost tromethamine for prevention of post-partum blood loss: A meta-analysis of randomized controlled trials. J Obstet Gynaecol Res. 2019 Jan;45(1):47-56. doi: 10.1111/jog.13833. Epub 2018 Oct 4. PMID: 30288846. 4: Zhang R, Shi H, Ren F, Yuan Z. Assessment of carboprost tromethamine for reducing hemorrhage in laparoscopic intramural myomectomy. Exp Ther Med. 2015 Sep;10(3):1171-1174. doi: 10.3892/etm.2015.2649. Epub 2015 Jul 20. PMID: 26622459; PMCID: PMC4533125. 5: Duan H, Hao M, Wang SM, Meng YJ, Wang Y, Yuan R, Xue X, Yang Q, Lin J, He YL, Shi YL, Liu JH, Wang X, Wang S. [Clinical multicenter study of carboprost methylate suppository for cervical ripening prior to diagnostic hysteroscopy]. Zhonghua Fu Chan Ke Za Zhi. 2018 Sep 25;53(9):602-607. Chinese. doi: 10.3760/cma.j.issn.0529-567x.2018.09.004. PMID: 30293295. 6: Sunil Kumar KS, Shyam S, Batakurki P. Carboprost Versus Oxytocin for Active Management of Third Stage of Labor: A Prospective Randomized Control Study. J Obstet Gynaecol India. 2016 Oct;66(Suppl 1):229-34. doi: 10.1007/s13224-016-0842-x. Epub 2016 Mar 22. PMID: 27651609; PMCID: PMC5016447. 7: Mozurkewich EL, Chilimigras JL, Berman DR, Perni UC, Romero VC, King VJ, Keeton KL. Methods of induction of labour: a systematic review. BMC Pregnancy Childbirth. 2011 Oct 27;11:84. doi: 10.1186/1471-2393-11-84. PMID: 22032440; PMCID: PMC3224350. 8: Yin L, Meng X, Zhou X, Zhang T, Sun H, Yang Z, Yang B, Xiao N, Fawcett JP, Yang Y, Gu J. Simultaneous determination of carboprost methylate and its active metabolite carboprost in dog plasma by liquid chromatography-tandem mass spectrometry with positive/negative ion-switching electrospray ionization and its application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Aug 15;998-999:8-14. doi: 10.1016/j.jchromb.2015.05.039. Epub 2015 Jun 25. PMID: 26149245. 9: Bai J, Sun Q, Zhai H. A comparison of oxytocin and carboprost tromethamine in the prevention of postpartum hemorrhage in high-risk patients undergoing cesarean delivery. Exp Ther Med. 2014 Jan;7(1):46-50. doi: 10.3892/etm.2013.1379. Epub 2013 Nov 1. PMID: 24348762; PMCID: PMC3861477. 10: Balki M, Erik-Soussi M, Ramachandran N, Kingdom J, Carvalho JC. The Contractile Effects of Oxytocin, Ergonovine, and Carboprost and Their Combinations: an In Vitro Study on Human Myometrial Strips. Anesth Analg. 2015 May;120(5):1074-84. doi: 10.1213/ANE.0000000000000682. PMID: 25822922.