Related CAS #
749-13-3 (free base); 2062-77-3 (HCl)
Synonym
Trifluperidol Free Base; P 459; P459; P-459; R2498; R 2498; R-2498
IUPAC/Chemical Name
1-Butanone, 1-(4-fluorophenyl)-4-(4-hydroxy-4-(3-(trifluoromethyl)phenyl)-1-piperidinyl)-
InChi Key
GPMXUUPHFNMNDH-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H23F4NO2/c23-19-8-6-16(7-9-19)20(28)5-2-12-27-13-10-21(29,11-14-27)17-3-1-4-18(15-17)22(24,25)26/h1,3-4,6-9,15,29H,2,5,10-14H2
SMILES Code
O=C(C1=CC=C(F)C=C1)CCCN2CCC(C3=CC=CC(C(F)(F)F)=C3)(O)CC2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
409.42
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Tarighati S, a'Brook MF. Trifluperidol in Huntington's chorea. Lancet. 1968 Aug 24;2(7565):458-9. doi: 10.1016/s0140-6736(68)90500-x. PMID: 4174183.
2: Janssen PA. The evolution of the butyrophenones, haloperidol and trifluperidol, from meperidine-like 4-phenylpiperidines. Int Rev Neurobiol. 1965;8:221-63. doi: 10.1016/s0074-7742(08)60759-x. PMID: 5321473.
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7: Singh SP, Giridhar C, Avasthi A. Neuroleptic malignant syndrome with trifluperidol. Br J Psychiatry. 1989 Oct;155:561-3. doi: 10.1192/bjp.155.4.561. PMID: 2611583.
8: Kowalski J, Labuzek K, Herman ZS. Flupentixol and trifluperidol reduce interleukin-1 beta and interleukin-2 release by rat mixed glial and microglial cell cultures. Pol J Pharmacol. 2004 Sep-Oct;56(5):563-70. PMID: 15591644.
9: PRATT JP, BISHOP MP, GALLANT DM. TRIFLUPERIDOL AND HALOPERIDOL IN THE TREATMENT OF ACUTE SCHIZOPHRENIA. Am J Psychiatry. 1964 Dec;121:592-4. doi: 10.1176/ajp.121.6.592. PMID: 14239462.
10: Pandey A, Sharma M. Reappraisal of trifluperidol against Nsp3 as a potential therapeutic for novel COVID-19: a molecular docking and dynamics study. Future Virol. 2021 Jun:10.2217/fvl-2020-0361. doi: 10.2217/fvl-2020-0361. Epub 2021 Jul 13. PMID: 34290823; PMCID: PMC8285112.
