CRX-527 is a TLR4 ligand. CRX-527 induced differentiation of HSCs protecting the intestinal epithelium from radiation damage. Administration of CRX-527 improved the survival rate of total body irradiation (TBI) to 100% in wild-type mice but not in TLR4-/- mice. After TBI, hematopoietic system damage was significantly alleviated, and the recovery period was accelerated in CRX-527-treated mice. Moreover, CRX-527 induced differentiation of HSCs and the stimulation of CRX-527 significantly increased the proportion and number of LSK cells and promoted their differentiation into macrophages, activating immune defense.
MedKoo Cat#: 463262
Name: CRX-527
CAS#: 216014-14-1 (CRX-527)
Chemical Formula: C81H151N2O19P
Exact Mass: 1487.0649
Molecular Weight: 1488.07
Elemental Analysis: C, 65.38; H, 10.23; N, 1.88; O, 20.43; P, 2.08
The following data is based on the product molecular weight 1,488.07 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
