L-742001 | CAS#174605-64-2 | RNA polymerase inhibitor

MedKoo Cat#: 558372 | Name: L-742001 Hydrochloride

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

L-742001 Hydrochloride is an inhibitor of RNA polymerase.

Chemical Structure

L-742001 Hydrochloride

CAS#174605-64-2

Theoretical Analysis

MedKoo Cat#: 558372

Name: L-742001 Hydrochloride

CAS#: 174605-64-2

Chemical Formula: C23H25Cl2NO4

Exact Mass: 449.1161

Molecular Weight: 450.36

Elemental Analysis: C, 61.34; H, 5.60; Cl, 15.74; N, 3.11; O, 14.21

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 385.00	2 Weeks
25mg	USD 1,050.00	2 Weeks

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Related CAS #

177592-42-6

Synonym

L-742001; L 742001; L742001; L-742001 Hydrochloride; L 742001 Hydrochloride; L742001 Hydrochloride;

IUPAC/Chemical Name

4-[4-[(4-Chlorophenyl)methyl]-1-(phenylmethyl)-4-piperidinyl]-2-hydroxy-4-oxo-2-butenoic acid Hydrochloride

InChi Key

LMLNSXCRZNNZBT-VSOKSMTPSA-N

InChi Code

InChI=1S/C23H24ClNO4.ClH/c24-19-8-6-17(7-9-19)15-23(21(27)14-20(26)22(28)29)10-12-25(13-11-23)16-18-4-2-1-3-5-18;/h1-9,14,26H,10-13,15-16H2,(H,28,29);1H/b20-14-;

SMILES Code

O=C(O)/C(O)=C/C(C1(CC2=CC=C(Cl)C=C2)CCN(CC3=CC=CC=C3)CC1)=O.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

L-742001 Hydrochloride is an inhibitor of RNA polymerase.

In vitro activity:

The endonuclease activity was not affected by ATPase inhibitors, with the exception of N-ethylmaleimide (NEM), or by GTPase inhibitors, but it was decreased by treatment with the endonuclease inhibitor L-742001. Reference: Arch Virol. 2019 Aug;164(8):2091-2106. https://pubmed.ncbi.nlm.nih.gov/31139938/

In vivo activity:

TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 450.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Chen JK, Hsiao C, Wu JS, Lin SY, Wang CY. Characterization of the endonuclease activity of the replication-associated protein of beak and feather disease virus. Arch Virol. 2019 Aug;164(8):2091-2106. doi: 10.1007/s00705-019-04292-z. Epub 2019 May 29. PMID: 31139938. 2. Yan Z, Zhang L, Fu H, Wang Z, Lin J. Design of the influenza virus inhibitors targeting the PA endonuclease using 3D-QSAR modeling, side-chain hopping, and docking. Bioorg Med Chem Lett. 2014 Jan 15;24(2):539-47. doi: 10.1016/j.bmcl.2013.12.026. Epub 2013 Dec 12. PMID: 24365156.

In vitro protocol:

In vivo protocol:

TBD

1: Yan Z, Zhang L, Fu H, Wang Z, Lin J. Design of the influenza virus inhibitors targeting the PA endonuclease using 3D-QSAR modeling, side-chain hopping, and docking. Bioorg Med Chem Lett. 2014 Jan 15;24(2):539-47. doi: 10.1016/j.bmcl.2013.12.026. Epub 2013 Dec 12. PubMed PMID: 24365156.