Synonym
T16Ainh-A01; T16Ainh A01; T16AinhA01; T16A(inh)-A01; T16A(inh) A01; T16A(inh)A01;
IUPAC/Chemical Name
2-[(5-ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]-acetamide
InChi Key
QSIYTNYMBWYHAA-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H20N4O3S2/c1-4-14-11(2)20-18(23-17(14)25)28-10-16(24)22-19-21-15(9-27-19)12-5-7-13(26-3)8-6-12/h5-9H,4,10H2,1-3H3,(H,20,23,25)(H,21,22,24)
SMILES Code
O=C(NC1=NC(C2=CC=C(OC)C=C2)=CS1)CSC3=NC(C)=C(CC)C(N3)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
416.51
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Fujii N, Amano T, Kenny GP, Mündel T, Lei TH, Honda Y, Kondo N, Nishiyasu T.
TMEM16A blockers T16Ainh-A01 and benzbromarone do not modulate the regulation of
sweating and cutaneous vasodilatation in humans in vivo. Exp Physiol. 2022
Aug;107(8):844-853. doi: 10.1113/EP090521. Epub 2022 Jun 22. PMID: 35688020.
2: Tian XQ, Ma KT, Wang XW, Wang Y, Guo ZK, Si JQ. Effects of the Calcium-
Activated Chloride Channel Inhibitors T16Ainh-A01 and CaCCinh-A01 on Cardiac
Fibroblast Function. Cell Physiol Biochem. 2018;49(2):706-716. doi:
10.1159/000493036. Epub 2018 Aug 30. PMID: 30165368.
3: Feng ZY, Li XR, Chen L, Zhou Y, Chang YC, Ma KT, Si JQ, Li L. [Effects of
T16Ainh-A01 on the apoptosis and senescence of endothelial cells in the cochlea
stria vascularis]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2020
Sep;36(5):385-389. Chinese. doi: 10.12047/j.cjap.5959.2020.082. PMID: 33629548.
