Synonym
Tyrosylleucine; Tyr-leu; L-Tyrosyl-L-leucine;
IUPAC/Chemical Name
L-tyrosyl-L-leucine
InChi Key
AUEJLPRZGVVDNU-STQMWFEESA-N
InChi Code
InChI=1S/C15H22N2O4/c1-9(2)7-13(15(20)21)17-14(19)12(16)8-10-3-5-11(18)6-4-10/h3-6,9,12-13,18H,7-8,16H2,1-2H3,(H,17,19)(H,20,21)/t12-,13-/m0/s1
SMILES Code
CC(C)C[C@@H](C(O)=O)NC([C@H](CC1=CC=C(O)C=C1)N)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
294.35
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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2: Mizushige T, Kanegawa N, Yamada A, Ota A, Kanamoto R, Ohinata K. Aromatic amino acid-leucine dipeptides exhibit anxiolytic-like activity in young mice. Neurosci Lett. 2013 May 24;543:126-9. doi: 10.1016/j.neulet.2013.03.043. Epub 2013 Apr 6. PubMed PMID: 23570730.
3: Domingues P, Fonseca C, Reis A, Domingues MR. Identification of isomeric spin adducts of Leu-Tyr and Tyr-Leu free radicals using liquid chromatography-tandem mass spectrometry. Biomed Chromatogr. 2012 Jan;26(1):51-60. doi: 10.1002/bmc.1624. Epub 2011 Mar 23. PubMed PMID: 21432862.
4: Kanegawa N, Suzuki C, Ohinata K. Dipeptide Tyr-Leu (YL) exhibits anxiolytic-like activity after oral administration via activating serotonin 5-HT1A, dopamine D1 and GABAA receptors in mice. FEBS Lett. 2010 Feb 5;584(3):599-604. doi: 10.1016/j.febslet.2009.12.008. Epub 2009 Dec 23. PubMed PMID: 20005875.
5: Chen Y, Zhang L, Cai Z, Chen G. Dynamic pH junction-sweeping for on-line focusing of dipeptides in capillary electrophoresis with laser-induced fluorescence detection. Analyst. 2011 May 7;136(9):1852-8. doi: 10.1039/c0an00744g. Epub 2011 Mar 11. PubMed PMID: 21394345.
6: Mullally MM, Meisel H, FitzGerald RJ. Synthetic peptides corresponding to alpha-lactalbumin and beta-lactoglobulin sequences with angiotensin-I-converting enzyme inhibitory activity. Biol Chem Hoppe Seyler. 1996 Apr;377(4):259-60. PubMed PMID: 8737991.
7: Fonseca C, Domingues MR, Simões C, Amado F, Domingues P. Reactivity of Tyr-Leu and Leu-Tyr dipeptides: identification of oxidation products by liquid chromatography-tandem mass spectrometry. J Mass Spectrom. 2009 May;44(5):681-93. doi: 10.1002/jms.1543. PubMed PMID: 19125397.
8: Gardner ML, Mitchell CJ. Studies on the absorption of the pancreatic function test peptide, N-benzoyl-L-tyrosyl-p-aminobenzoic acid, and related compounds by isolated rat small intestine. Q J Exp Physiol. 1981 Jan;66(1):17-24. PubMed PMID: 6973773.
