ZSA-215 is a potent STING agonist. ZSA-215 enhanced STINGsignaling through promoting the phosphorylation of STING andinterferon regulatory factor 3 (IRF3) and secretion of IFN-β.Notably, monotherapy of oral ZSA-215 achieved complete tumorregression and long-term survival of mice in MC38 colon cancermodel, which is superior to MSA-2. Furthermore, ZSA-215exhibited excellent metabolic and chemical stability in vitro, high oral drug exposure (AUC = 23835.0 h·ng/mL) and bioavailability(F = 58%).
MedKoo Cat#: 128988
Name: ZSA-215
CAS#: N/A
Chemical Formula: C14H14FNO5S
Exact Mass: 327.0577
Molecular Weight: 327.33
Elemental Analysis: C, 51.37; H, 4.31; F, 5.80; N, 4.28; O, 24.44; S, 9.79
The following data is based on the product molecular weight 327.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
