IUPAC/Chemical Name
Formamide, N-(4-(5-nitro-2-furanyl)-2-thiazolyl)-
InChi Key
ZQBWQLJJMGJREB-UHFFFAOYSA-N
InChi Code
InChI=1S/C8H5N3O4S/c12-4-9-8-10-5(3-16-8)6-1-2-7(15-6)11(13)14/h1-4H,(H,9,10,12)
SMILES Code
O=CNC1=NC(C2=CC=C([N+]([O-])=O)O2)=CS1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
239.21
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Dawley RM, Lakshmi VM, Babu SR, Zenser TV, Davis BB. Liver NADPH-dependent oxidation of the 5-nitrofurans, FANFT and ANFT, by guinea pig and rat. Xenobiotica. 1993 Feb;23(2):193-203. doi: 10.3109/00498259309059374. PMID: 8498082.
2: Sawczuk IS, Walsh W, King W, Olsson CA, Nguyen-Huu C. Enhanced expression of Harvey-ras oncogene in FANFT-induced transitional cell carcinoma. Urol Int. 1987;42(5):321-5. doi: 10.1159/000281983. PMID: 3433577.
3: Anderström C, Johansson SL, von Schultz L. The influence of phenacetin or mechanical perforation on the development of renal pelvic and urinary bladder tumors in FANFT-induced urinary tract carcinogenesis. Acta Pathol Microbiol Immunol Scand A. 1983 Sep;91(5):373-80. doi: 10.1111/j.1699-0463.1983.tb02768.x. PMID: 6613585.
4: Pauli BU, Cohen SM, Weinstein RS. Cellular changes in rat urinary bladder carcinomas induced by FANFT: a quantitative electron microscopic analysis. J Urol. 1983 Mar;129(3):646-52. doi: 10.1016/s0022-5347(17)52271-5. PMID: 6834570.
5: Crabtree WN, Soloway MS, Matheny RB Jr, Murphy WM. Metastatic characteristics of four FANFT-induced murine bladder tumors. Urology. 1983 Nov;22(5):529-31. doi: 10.1016/0090-4295(83)90235-2. PMID: 6649210.
6: Drago JR. The Noble rat bladder cancer model. FANFT-induced tumors. Cancer. 1984 Mar 1;53(5):1093-9. doi: 10.1002/1097-0142(19840301)53:5<1093::aid- cncr2820530513>3.0.co;2-8. PMID: 6692301.
7: Mickey DD, Mickey GH, Murphy WM, Niell HB, Soloway MS. In vitro characterization of four N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide (FANFT) induced mouse bladder tumors. J Urol. 1982 Jun;127(6):1233-7. doi: 10.1016/s0022-5347(17)54305-0. PMID: 7087044.
8: Debiec-Rychter M, Jones RF, Zukowski K, Wang CY. Oncogene expression of FANFT- or BBN-induced rat urothelial cells. Int J Cancer. 1990 Nov 15;46(5):913-8. doi: 10.1002/ijc.2910460527. PMID: 2228319.
9: Soloway MS, Cohen SM, Dekernion JB, Persky L. Failure of ascorbic acid to inhibit FANFT-induced bladder cancer. J Urol. 1975 Apr;113(4):483-6. doi: 10.1016/s0022-5347(17)59506-3. PMID: 1117519.
10: Cohen SM, Ellwein LB, Okamura T, Masui T, Johansson SL, Smith RA, Wehner JM, Khachab M, Chappel CI, Schoenig GP, et al. Comparative bladder tumor promoting activity of sodium saccharin, sodium ascorbate, related acids, and calcium salts in rats. Cancer Res. 1991 Apr 1;51(7):1766-77. PMID: 2004360.
