MedKoo Cat#: 330056 | Name: Prothixene
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Prothixene is a biochemical with potential thymo-analeptic action. prothixene had no effect on heart rate in isolated rabbit and cat hearts, but the amplitude of the contractions was reduced.

Chemical Structure

Prothixene
Prothixene
CAS#2622-24-4 (free base)

Theoretical Analysis

MedKoo Cat#: 330056

Name: Prothixene

CAS#: 2622-24-4 (free base)

Chemical Formula: C18H21NS

Exact Mass: 283.1395

Molecular Weight: 283.43

Elemental Analysis: C, 76.28; H, 7.47; N, 4.94; S, 11.31

Price and Availability

Size Price Availability Quantity
200mg USD 1,250.00 2 Weeks
500mg USD 1,950.00 2 Weeks
1g USD 2,950.00 2 Weeks
2g USD 5,250.00 2 Weeks
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Synonym
Prothixene; Prothixene [INN]; Prothixenum; Protixeno
IUPAC/Chemical Name
10-(3-Dimethylaminopropyliden)thioxanthen
InChi Key
MNJIUAXMUGFJJV-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H21NS/c1-19(2)12-7-13-20-17-10-5-3-8-15(17)14-16-9-4-6-11-18(16)20/h3-6,8-11,13H,7,12,14H2,1-2H3
SMILES Code
CN(CC/C=S1C2=C(C=CC=C2)CC3=C\1C=CC=C3)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 283.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Vinogradov VV, Krylov SS. K farmakologii prooksena [Pharmacology of prooxen]. Farmakol Toksikol. 1980 Sep-Oct;43(5):563-6. Russian. PMID: 7449985. 2: Metys J, Metysová J, Votava Z. Srovnání farmakologických vlastností prothixenu, promethazinu a chlorprothixenu [Comparison of the pharmacological properties of prothixene, promethazine and chlorprothixene]. Cesk Farm. 1966 Dec;15(10):526-30. Czech. PMID: 4382828. 3: Jílek JO, Rajsner M, Pomykácek J, Protiva M. Synthetická ataraktika. XII. Prothixen a analogy. Nová synthesa chlorprothixenu [Synthetic ataraxics. XII. Prothixene and analogues. A new synthesis of chlorprothixene]. Cesk Farm. 1965 Aug;14(6):294-303. Czech. PMID: 5852321. 4: Scheckel, C. L. (1969). Pharmacology and chemistry of the thioxanthenes with special reference to chlorprothixene. In The Thioxanthenes (Vol. 2, pp. 1-14). Karger Publishers.