ZJ-43 | CAS# 723331-20-2 | NAALADase, NAAG peptidase inhibitor

MedKoo Cat#: 574946 | Name: ZJ-43

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ZJ-43 is an inhibitor of glutamate carboxypeptidase II and III (GCP II and III/NAAG peptidase/NAALADase) that inhibits the hydrolysis of NAAG.

Chemical Structure

ZJ-43

CAS#723331-20-2

Theoretical Analysis

MedKoo Cat#: 574946

Name: ZJ-43

CAS#: 723331-20-2

Chemical Formula: C12H20N2O7

Exact Mass: 304.1271

Molecular Weight: 304.30

Elemental Analysis: C, 47.37; H, 6.63; N, 9.21; O, 36.80

Price and Availability

This product was removed for the commercial reasons.

Related CAS #

No Data

Synonym

ZJ 43; ZJ43; ZJ-43

IUPAC/Chemical Name

N-[[[(1S)-1-Carboxy-3-methylbutyl]amino]carbonyl]-L-glutamic acid

InChi Key

BSGWCSGMXAVYRT-YUMQZZPRSA-N

InChi Code

InChI=1S/C12H20N2O7/c1-6(2)5-8(11(19)20)14-12(21)13-7(10(17)18)3-4-9(15)16/h6-8H,3-5H2,1-2H3,(H,15,16)(H,17,18)(H,19,20)(H2,13,14,21)/t7-,8-/m0/s1

SMILES Code

O=C(O)CC[C@@H](C(O)=O)NC(N[C@H](C(O)=O)CC(C)C)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 304.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Olszewski et al (2004) NAAG peptidase inhibition reduces locomotor activity and some stereotypes in the PCP model of schizophrenia via group II mGluR. J.Neurochem. 89 876 PMID: 15140187 2. Zhou et al (2005) NAAG peptidase inhibitors and their potential for diagnosis and therapy. Nat.Rev.Drug Discov. 4 1015 PMID: 16341066 3. Yamamoto et al (2007) Local administration of N-acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in peripheral pain in rats. Eur.J.Neurosci. 25 147 PMID: 17241276