Synonym
TT01001; TT-01001; TT 01001;
IUPAC/Chemical Name
Ethyl 4-(3-(3,5-dichlorophenyl)thioureido)piperidine-1-carboxylate
InChi Key
IBKBNNZZQOIWCI-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H19Cl2N3O2S/c1-2-22-15(21)20-5-3-12(4-6-20)18-14(23)19-13-8-10(16)7-11(17)9-13/h7-9,12H,2-6H2,1H3,(H2,18,19,23)
SMILES Code
O=C(N1CCC(NC(NC2=CC(Cl)=CC(Cl)=C2)=S)CC1)OCC
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
376.29
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Takahashi T, Yamamoto M, Amikura K, Kato K, Serizawa T, Serizawa K, Akazawa D, Aoki T, Kawai K, Ogasawara E, Hayashi J, Nakada K, Kainoh M. A novel MitoNEET ligand, TT01001, improves diabetes and ameliorates mitochondrial function in db/db mice. J Pharmacol Exp Ther. 2015 Feb;352(2):338-45. doi: 10.1124/jpet.114.220673. Epub 2014 Dec 12. PubMed PMID: 25503385.
Shi G, Cui L, Chen R, Liang S, Wang C, Wu P. TT01001 attenuates oxidative stress and neuronal apoptosis by preventing mitoNEET-mediated mitochondrial dysfunction after subarachnoid hemorrhage in rats. Neuroreport. 2020 Aug 5;31(11):845-850. doi: 10.1097/WNR.0000000000001492. PMID: 32604395.
Barbosa Belchior M, Kane RT, Huber JD, Geldenhuys WJ. Synthesis and evaluation of enzyme inhibition by novel TT01001 derivatives as monoamine oxidase B inhibitors. Bioorg Med Chem Lett. 2024 Dec 2;117:130045. doi: 10.1016/j.bmcl.2024.130045. Epub ahead of print. PMID: 39631473.
