NA 382 | CAS#143086-33-3 | Multidrug Resistance Inhibitor

MedKoo Cat#: 110222 | Name: NA 382

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NA 382 is a staurosporine derivative that inhibits multidrug resistance.

Chemical Structure

NA 382

CAS#143086-33-3

Theoretical Analysis

MedKoo Cat#: 110222

Name: NA 382

CAS#: 143086-33-3

Chemical Formula: C31H28N4O6

Exact Mass: 552.2009

Molecular Weight: 552.59

Elemental Analysis: C, 67.38; H, 5.11; N, 10.14; O, 17.37

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

N-Ethoxycarbonyl-7-oxostaurosporine; NA 382; NA-382; NA382

IUPAC/Chemical Name

Carbamic acid, (2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-1,3-dioxo-9,13-epoxy-1H,9H-diindolo(1,2,3-gh:3',2',1'-lm)pyrrolo(3,4-j)(1,7)benzodiazonin-11-yl)methyl-, ethyl ester, (9alpha,10beta,11beta,13alpha)-

InChi Key

YYDZNUMDZXMMCI-ZEMYHKRKSA-N

InChi Code

InChI=1S/C31H28N4O6/c1-5-40-30(38)33(3)19-14-20-34-17-12-8-6-10-15(17)21-23-24(29(37)32-28(23)36)22-16-11-7-9-13-18(16)35(26(22)25(21)34)31(2,41-20)27(19)39-4/h6-13,19-20,27H,5,14H2,1-4H3,(H,32,36,37)/t19-,20+,27+,31+/m1/s1

SMILES Code

CCOC(N([C@]([C@@](OC)([H])[C@@]12C)([H])C[C@@](O2)([H])N3C4=CC=CC=C4C5=C(C(O)=NC6=O)C6=C7C8=CC=CC=C8N1C7=C53)C)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 552.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Miyamoto K, Inoko K, Wakusawa S, Kajita S, Hasegawa T, Takagi K, Koyama M. Inhibition of multidrug resistance by a new staurosporine derivative, NA-382, in vitro and in vivo. Cancer Res. 1993 Apr 1;53(7):1555-9. PMID: 8095855.