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MedKoo Cat#: 407470 | Name: KRCA-0713

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KRCA-0713 is a ALK inhibitor.

Chemical Structure

KRCA-0713
KRCA-0713
CAS#1884321-89-4

Theoretical Analysis

MedKoo Cat#: 407470

Name: KRCA-0713

CAS#: 1884321-89-4

Chemical Formula: C26H32ClN5O3S

Exact Mass: 529.1914

Molecular Weight: 530.08

Elemental Analysis: C, 58.91; H, 6.09; Cl, 6.69; N, 13.21; O, 9.05; S, 6.05

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
KRCA-0713; KRCA 0713; KRCA0713.
IUPAC/Chemical Name
N2-(6-amino-3-methoxy-5,5-dimethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-5-chloro-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine
InChi Key
WMLFTPJTSQTLNL-UHFFFAOYSA-N
InChi Code
InChI=1S/C26H32ClN5O3S/c1-15(2)36(33,34)22-9-7-6-8-19(22)30-24-18(27)14-29-25(32-24)31-20-12-16-10-11-23(28)26(3,4)17(16)13-21(20)35-5/h6-9,12-15,23H,10-11,28H2,1-5H3,(H2,29,30,31,32)
SMILES Code
ClC1=CN=C(N=C1NC2=CC=CC=C2S(C(C)C)(=O)=O)NC3=C(C=C4C(C)(C)C(N)CCC4=C3)OC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 530.08 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Achary R, Mathi GR, Lee DH, Yun CS, Lee CO, Kim HR, Park CH, Kim P, Hwang JY. Novel 2,4-diaminopyrimidines bearing fused tricyclic ring moiety for anaplastic lymphoma kinase (ALK) inhibitor. Bioorg Med Chem Lett. 2017 May 15;27(10):2185-2191. doi: 10.1016/j.bmcl.2017.03.073. Epub 2017 Mar 29. PubMed PMID: 28385505.

View History

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