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MedKoo Cat#: 527602 | Name: TT-301

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TT-301, also known as MW-189, is a cytokine inhibitor and glial cell inhibitor potentially for the treatment of traumatic brain injury.

Chemical Structure

TT-301
TT-301
CAS#886208-76-0 (free base)

Theoretical Analysis

MedKoo Cat#: 527602

Name: TT-301

CAS#: 886208-76-0 (free base)

Chemical Formula: C23H21N7

Exact Mass: 395.1858

Molecular Weight: 395.47

Elemental Analysis: C, 69.85; H, 5.35; N, 24.79

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
1346545-21-8 (HCl) 886208-76-0 (free base)
Synonym
TT-301; TT 301; TT301; MW-189; MW 189 ;MW189
IUPAC/Chemical Name
6-phenyl-4-(pyridin-4-yl)-3-(4-(pyrimidin-2-yl)piperazin-1-yl)pyridazine
InChi Key
ZPJGUEPHFXPAQF-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H21N7/c1-2-5-19(6-3-1)21-17-20(18-7-11-24-12-8-18)22(28-27-21)29-13-15-30(16-14-29)23-25-9-4-10-26-23/h1-12,17H,13-16H2
SMILES Code
C1(C2=CC(C3=CC=NC=C3)=C(N4CCN(C5=NC=CC=N5)CC4)N=N2)=CC=CC=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 395.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: James ML, Wang H, Cantillana V, Lei B, Kernagis DN, Dawson HN, Klaman LD, Laskowitz DT. TT-301 inhibits microglial activation and improves outcome after central nervous system injury in adult mice. Anesthesiology. 2012 Jun;116(6):1299-311. doi: 10.1097/ALN.0b013e318253a02a. PubMed PMID: 22487803.