MedKoo Cat#: 574934 | Name: Vatalanib succinate
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Vatalanib succinate is a VEGFR, PDGFR-β, c-Kit, c-Fms, and aromatase inhibitor.

Chemical Structure

Vatalanib succinate
Vatalanib succinate
CAS#212142-18-2 (succinate)

Theoretical Analysis

MedKoo Cat#: 574934

Name: Vatalanib succinate

CAS#: 212142-18-2 (succinate)

Chemical Formula: C24H21ClN4O4

Exact Mass: 464.1251

Molecular Weight: 464.91

Elemental Analysis: C, 62.00; H, 4.55; Cl, 7.63; N, 12.05; O, 13.77

Price and Availability

Size Price Availability Quantity
10mg USD 395.00 2 Weeks
50mg USD 1,150.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Synonym
CGP 79787D, PTK787/ZK222584; Vatalanib succinate
IUPAC/Chemical Name
N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine succinate
InChi Key
LLDWLPRYLVPDTG-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H15ClN4.C4H6O4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14;5-3(6)1-2-4(7)8/h1-12H,13H2,(H,23,25);1-2H2,(H,5,6)(H,7,8)
SMILES Code
ClC1=CC=C(NC2=NN=C(CC3=CC=NC=C3)C4=C2C=CC=C4)C=C1.O=C(O)CCC(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 464.91 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Banerjee et al (2009) The vascular endothelial growth factor receptor inhibitor PTK787/ZK222584 inhibits aromatase. Cancer Res. 69 4716 PMID: 19435899 2. Wood et al (2000) PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res. 60 2178 PMID: 10786682 3. Bold et al (2000) New anilinophthalazines as potent and orally well absorbed inhibitors of the VEGF receptor tyrosine kinases useful as antagonists of tumor-driven angiogenesis. J.Med.Chem. 43 2310 PMID: 10956229