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MedKoo Cat#: 412194 | Name: Neomycin (free base)

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Neomycin (free base) is an antibiotic complex produced by Streptomyces fradiae. It is composed of neomycins A, B, and C. It acts by inhibiting translation during protein synthesis.

Chemical Structure

Neomycin (free base)
Neomycin (free base)
CAS#1404-04-2 (free base)

Theoretical Analysis

MedKoo Cat#: 412194

Name: Neomycin (free base)

CAS#: 1404-04-2 (free base)

Chemical Formula: C23H46N6O13

Exact Mass: 614.3123

Molecular Weight: 614.65

Elemental Analysis: C, 44.94; H, 7.54; N, 13.67; O, 33.84

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
55298-68-5 (palmitate) 1406-04-8 (undecylenate) 1404-04-2 (free base) 1405-10-3 (sulfate) 4146-30-9 (B sulfate)
Synonym
Neomycin (free base); HSDB3242; HSDB-3242; HSDB 3242
IUPAC/Chemical Name
(2S,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-(((2R,3S,4R,5S)-5-(((1R,2R,3S,5R,6S)-3,5-diamino-2-(((2R,3R,4R,5S,6R)-3-amino-6-(aminomethyl)-4,5-dihydroxytetrahydro-2H-pyran-2-yl)oxy)-6-hydroxycyclohexyl)oxy)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl)oxy)tetrahydro-2H-pyran-3,4-diol
InChi Key
PGBHMTALBVVCIT-VCIWKGPPSA-N
InChi Code
InChI=1S/C23H46N6O13/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22/h5-23,30-36H,1-4,24-29H2/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1
SMILES Code
NC[C@@H]1O[C@@H]([C@@H]([C@H]([C@@H]1O)O)N)O[C@H]2[C@H]([C@@H](O[C@@H]2CO)O[C@@H]3[C@H]([C@@H](C[C@@H]([C@H]3O[C@H]4O[C@@H]([C@H]([C@@H]([C@H]4N)O)O)CN)N)N)O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 614.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Robinson KA, Dunn M, Hussey SP, Fritz-Laylin LK. Identification of antibiotics for use in selection of the chytrid fungi Batrachochytrium dendrobatidis and Batrachochytrium salamandrivorans. PLoS One. 2020 Oct 20;15(10):e0240480. doi: 10.1371/journal.pone.0240480. PMID: 33079945. 2: Kovacik A, Tvrda E, Jambor T, Fulopova D, Kovacikova E, Hleba L, Kołodziejczyk ŁM, Hlebova M, Gren A, Massanyi P. Cytotoxic effect of aminoglycoside antibiotics on the mammalian cell lines. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2020 Oct 10:1-8. doi: 10.1080/10934529.2020.1830653. Epub ahead of print. PMID: 33040680. 3: El-Ashker M, Gwida M, Monecke S, Ehricht R, Elsayed M, El-Gohary F, Reißig A, Müller E, Paul A, Igbinosa EO, Beshiru A, Maurischat S. Microarray-based detection of resistance genes in coagulase-negative staphylococci isolated from cattle and buffalo with mastitis in Egypt. Trop Anim Health Prod. 2020 Oct 7. doi: 10.1007/s11250-020-02424-1. Epub ahead of print. PMID: 33026613. 4: Rastogi R, Kapoor A, Verma JK, Ansari I, Sood C, Kumar K, Mukhopadhyay A. Rab5b function is essential to acquire heme from hemoglobin endocytosis for survival of Leishmania. Biochim Biophys Acta Mol Cell Res. 2020 Oct 2;1868(1):118868. doi: 10.1016/j.bbamcr.2020.118868. Epub ahead of print. PMID: 33011192. 5: Zhong Z, Fu X, Li H, Chen J, Wang M, Gao S, Zhang L, Cheng C, Zhang Y, Li P, Zhang S, Qian X, Shu Y, Chai R, Gao X. Citicoline Protects Auditory Hair Cells Against Neomycin-Induced Damage. Front Cell Dev Biol. 2020 Aug 31;8:712. doi: 10.3389/fcell.2020.00712. PMID: 32984303; PMCID: PMC7487320. 6: Emmady PD, Murr N. EEG Triphasic Waves. 2020 Sep 25. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan–. PMID: 32491611. 7: Bi L, Luan X, Geng F, Xu X, Chen Y, Zhang F. Microwave-Assisted Synthesis of Hollow Microspheres with Multicomponent Nanocores for Heavy-Metal Removal and Magnetic Sensing. ACS Appl Mater Interfaces. 2020 Oct 14;12(41):46779-46787. doi: 10.1021/acsami.0c14298. Epub 2020 Oct 1. PMID: 32965095. 8: Chalder RH, Knott T, Rushton JO, Nikolic-Pollard D. Changes in antimicrobial resistance patterns of ocular surface bacteria isolated from horses in the UK: An eight-year surveillance study (2012-2019). Vet Ophthalmol. 2020 Sep 22. doi: 10.1111/vop.12827. Epub ahead of print. PMID: 32961021. 9: Koutsianos D, Athanasiou LV, Dimitriou T, Nikolaidis M, Tsadila C, Amoutzias G, Mossialos D, Koutoulis KC. Antibiotic Resistance Patterns and mcr-1 Detection in Avian Pathogenic Escherichia coli Isolates from Commercial Layer and Layer Breeder Flocks Demonstrating Colibacillosis in Greece. Microb Drug Resist. 2020 Sep 21. doi: 10.1089/mdr.2020.0057. Epub ahead of print. PMID: 32955987. 10: Jang DH, Lee JI, Bae JY, Jung HJ, Park MY, Ahn J. Facial erythema after the treatment of dupilumab in SLE patient. Allergy Asthma Clin Immunol. 2020 Jul 3;16:60. doi: 10.1186/s13223-020-00458-6. PMID: 32944024; PMCID: PMC7491356. 11: Gujral J, Costin G, Khurana D, Yau M, Wallach E, Romero CJ, Wilkes M, Sethuram S, Rapaport R. Undervirilized male infant with in utero exposure to maternal use of high dose antifungal therapy. Int J Pediatr Endocrinol. 2020;2020:16. doi: 10.1186/s13633-020-00087-1. Epub 2020 Sep 9. PMID: 32944019; PMCID: PMC7488073. 12: Mitra M, Nguyen KM, Box TW, Gilpin JS, Hamby SR, Berry TL, Duckett EH. Isolation and characterization of a novel Sphingobium yanoikuyae strain variant that uses biohazardous saturated hydrocarbons and aromatic compounds as sole carbon sources. F1000Res. 2020 Jul 24;9:767. doi: 10.12688/f1000research.25284.1. PMID: 32934808; PMCID: PMC7477647. 13: Bian Y, Scofield-Kaplan SM, Zemsky C, Campagnoli T, Ghadiali L, Dagi Glass LR, Sallee B, Belsito DV, Winn BJ. Punctal Congestion Syndrome: A Reversible, Functional Punctal Stenosis Causing Epiphora in the Setting of Chronic Pretarsal Conjunctivitis. Ophthalmic Plast Reconstr Surg. 2020 Aug 25. doi: 10.1097/IOP.0000000000001840. Epub ahead of print. PMID: 32890120. 14: Slopnick EA, Welles Henderson J, Chapman G, Sheyn DD, El-Nashar SA, Petrikovets A, Pollard R, Mangel JM. Cystoscopy with antibiotic irrigation during pelvic reconstruction and minimally invasive gynecologic surgery: A double-blind randomized controlled trial. Neurourol Urodyn. 2020 Nov;39(8):2386-2393. doi: 10.1002/nau.24499. Epub 2020 Sep 4. PMID: 32886811. 15: Konerding W, Arenberg JG, Kral A, Baumhoff P. Late electrically-evoked compound action potentials as markers for acute micro-lesions of spiral ganglion neurons. Hear Res. 2020 Aug 18:108057. doi: 10.1016/j.heares.2020.108057. Epub ahead of print. PMID: 32883545. 16: Günzel C, Kühnl F, Arnold K, Findeiß S, Weinberg CE, Stadler PF, Mörl M. Beyond Plug and Pray: Context Sensitivity and in silico Design of Artificial Neomycin Riboswitches. RNA Biol. 2020 Sep 3. doi: 10.1080/15476286.2020.1816336. Epub ahead of print. PMID: 32882151. 17: Parra M, Espinoza D, Valdes N, Vargas R, Gonzalez A, Modak B, Tello M. Microbiota Modulates the Immunomodulatory Effects of Filifolinone on Atlantic Salmon. Microorganisms. 2020 Aug 30;8(9):E1320. doi: 10.3390/microorganisms8091320. PMID: 32872599. 18: Rapacz-Kmita A, Szaraniec B, MikoŁajczyk M, Stodolak-Zych E, Dzierzkowska E, Gajek M, Dudek P. Multifunctional biodegradable polymer/clay nanocomposites with antibacterial properties in drug delivery systems. Acta Bioeng Biomech. 2020;22(2):83-92. PMID: 32868936. 19: de Azevedo EC, Martins BTF, Tiba Casas MR, Possebon FS, Araújo Junior JP, Nero LA, Yamatogi RS. Multidrug Resistance and Virulence Profiles of Salmonella Isolated from Swine Lymph Nodes. Microb Drug Resist. 2020 Aug 28. doi: 10.1089/mdr.2020.0120. Epub ahead of print. PMID: 32865485. 20: Zheng J, Li Y, Guan H, Li J, Li D, Zhang J, Tan H. Component Optimization of Neomycin Biosynthesis via the Reconstitution of a Combinatorial Mini-Gene- Cluster in Streptomyces fradiae. ACS Synth Biol. 2020 Sep 18;9(9):2493-2501. doi: 10.1021/acssynbio.0c00281. Epub 2020 Aug 29. PMID: 32864952.