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MedKoo Cat#: 412183 | Name: Trimethoprim sulfate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Trimethoprim (TMP) is an antibiotic used mainly in the treatment of bladder infections. Trimethoprim binds to dihydrofolate reductase and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). THF is an essential precursor in the thymidine synthesis pathway and interference with this pathway inhibits bacterial DNA synthesis. Trimethoprim's inhibitory activity for bacterial dihydrofolate reductase is sixty thousand times greater than for human dihydrofolate reductase. Sulfamethoxazole inhibits dihydropteroate synthase, an enzyme involved further upstream in the same pathway.

Chemical Structure

Trimethoprim sulfate
Trimethoprim sulfate
CAS#56585-33-2 (sulfate)

Theoretical Analysis

MedKoo Cat#: 412183

Name: Trimethoprim sulfate

CAS#: 56585-33-2 (sulfate)

Chemical Formula: C28H38N8O10S

Exact Mass: 0.0000

Molecular Weight: 678.72

Elemental Analysis: C, 49.55; H, 5.64; N, 16.51; O, 23.57; S, 4.72

Price and Availability

Size Price Availability Quantity
100mg USD 150.00 2 Weeks
200mg USD 250.00 2 Weeks
500mg USD 450.00 2 Weeks
1g USD 750.00 4-6 weeks
2g USD 1,250.00 4-6 weeks
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Related CAS #
738-70-5 (free base) 56585-33-2 (sulfate) 23256-42-0 (lactate)
Synonym
Trimethoprim sulfate; BW72U; BW-72U; BW 72U
IUPAC/Chemical Name
5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine hemisulfate
InChi Key
UILMMYFRNCCPLK-UHFFFAOYSA-N
InChi Code
InChI=1S/2C14H18N4O3.H2O4S/c2*1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-5(2,3)4/h2*5-7H,4H2,1-3H3,(H4,15,16,17,18);(H2,1,2,3,4)
SMILES Code
NC1=NC=C(CC2=CC(OC)=C(OC)C(OC)=C2)C(N)=N1.O=S(O)(O)=O.NC3=NC=C(CC4=CC(OC)=C(OC)C(OC)=C4)C(N)=N3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 678.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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