Synonym
BW 540C; BW540-C; BW 540-C; BW-540-C
IUPAC/Chemical Name
1H-Pyrazol-3-amine, 4,5-dihydro-N-methyl-1-(3-(trifluoromethyl)phenyl)-
InChi Key
MWRJSSGQTGTSKH-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H12F3N3/c1-15-10-5-6-17(16-10)9-4-2-3-8(7-9)11(12,13)14/h2-4,7H,5-6H2,1H3,(H,15,16)
SMILES Code
FC(C1=CC(N2N=C(NC)CC2)=CC=C1)(F)F
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
243.23
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: van Wauwe JP, Goossens JG. Arabinogalactan- and dextran-induced ear inflammation in mice: differential inhibition by H1-antihistamines, 5-HT- serotonin antagonists and lipoxygenase blockers. Agents Actions. 1989 Aug;28(1-2):78-82. doi: 10.1007/BF02022984. PMID: 2476925.
2: Reynolds CH. Inactivation of soybean lipoxygenase by lipoxygenase inhibitors in the presence of 15-hydroperoxyeicosatetraenoic acid. Biochem Pharmacol. 1988 Dec 1;37(23):4531-7. doi: 10.1016/0006-2952(88)90669-7. PMID: 3144281.
3: Read NG, Astbury PJ, Morgan RJ, Parsons DN, Port CJ. Induction and exacerbation of hyaline droplet formation in the proximal tubular cells of the kidneys from male rats receiving a variety of pharmacological agents. Toxicology. 1988 Nov 14;52(1-2):81-101. doi: 10.1016/0300-483x(88)90198-9. PMID: 3188035.
4: Higgins AJ, Lees P, Sedgwick AD. Actions of BW540C in an equine model of acute inflammation: a preliminary study. Vet Q. 1987 Apr;9(2):103-10. doi: 10.1080/01652176.1987.9694086. PMID: 3039716.
5: Higgins AJ, Lees P, Sedgwick AD, Buick AR, Churchus R. Use of a novel non- steroidal anti-inflammatory drug in the horse. Equine Vet J. 1987 Jan;19(1):60-6. doi: 10.1111/j.2042-3306.1987.tb02584.x. PMID: 3691462.
6: Dawson B, Follenfant RL, Higgs GA, Schneider C, Gibson JR. The effect of BW 540C, a novel anti-inflammatory agent, on ultraviolet-induced physical and histological changes in guinea-pig skin. Br J Dermatol. 1985 Jul;113 Suppl 28:137-40. doi: 10.1111/j.1365-2133.1985.tb15644.x. PMID: 4015980.
