MedKoo Cat#: 412123 | Name: Pargeverine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pargeverine is a therapeutic agent used as premedication when performing endoscopic retrograde cholangiopancreatography (ERCP). Papaverine (Latin papaver, "poppy") is an opium alkaloid antispasmodic drug, used primarily in the treatment of visceral spasm and vasospasm (especially those involving the intestines, heart, or brain), and occasionally in the treatment of erectile dysfunction. It is used in the treatment of acute mesenteric ischemia. While it is found in the opium poppy, papaverine differs in both structure and pharmacological action from the analgesic morphine-like compounds.

Chemical Structure

Pargeverine
Pargeverine
CAS#13479-13-5 (free base)

Theoretical Analysis

MedKoo Cat#: 412123

Name: Pargeverine

CAS#: 13479-13-5 (free base)

Chemical Formula: C21H23NO3

Exact Mass: 337.1678

Molecular Weight: 337.42

Elemental Analysis: C, 74.75; H, 6.87; N, 4.15; O, 14.22

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Pargeverine; BE-50; BE50; BE 50
IUPAC/Chemical Name
2-(Dimethylamino)ethyl diphenyl(2-propynyloxy)acetate
InChi Key
QNPHCSSJLHAKSA-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H23NO3/c1-4-16-25-21(18-11-7-5-8-12-18,19-13-9-6-10-14-19)20(23)24-17-15-22(2)3/h1,5-14H,15-17H2,2-3H3
SMILES Code
O=C(OCCN(C)C)C(C1=CC=CC=C1)(C2=CC=CC=C2)OCC#C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 337.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: de los Santos AR, Martí ML, Di Girolamo G, Diego Espinosa J, Morano MA, Tobar JC, Del Prete C. Propinox in biliary colic: a multicenter, randomized, prospective and parallel double-blind study of three doses of propinox versus placebo in acute biliary colic pain. Int J Tissue React. 1999;21(1):13-8. PubMed PMID: 10463136. 2: Di Girolamo G, de los Santos AR, Martí ML, Valdés Quintana E, Godoy MI, Morano MA, Palomino G, Fandiño D, Greggio A. Propinox in intestinal colic: multicenter randomized prospective double-blind study of three doses of propinox vs. placebo in acute intestinal colic pain. Int J Clin Pharmacol Res. 2000;20(1-2):31-40. PubMed PMID: 11146900.