Pyrimethanil | CAS# 53112-28-0 | Fungicide

MedKoo Cat#: 574853 | Name: Pyrimethanil

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pyrimethanil is a broad spectrum anilino-pyrimidine foliar fungicide.

Chemical Structure

Pyrimethanil

CAS#53112-28-0

Theoretical Analysis

MedKoo Cat#: 574853

Name: Pyrimethanil

CAS#: 53112-28-0

Chemical Formula: C12H13N3

Exact Mass: 199.1109

Molecular Weight: 199.26

Elemental Analysis: C, 72.33; H, 6.58; N, 21.09

Price and Availability

Size	Price	Availability
1g	USD 210.00	2 Weeks
5g	USD 370.00	2 Weeks
10g	USD 585.00	2 Weeks
25g	USD 875.00	2 Weeks

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Related CAS #

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Synonym

Mythos; Pyrimethanil; Penbotec; Scala

IUPAC/Chemical Name

4,6-Dimethyl-N-phenyl-2-pyrimidinamine

InChi Key

ZLIBICFPKPWGIZ-UHFFFAOYSA-N

InChi Code

InChI=1S/C12H13N3/c1-9-8-10(2)14-12(13-9)15-11-6-4-3-5-7-11/h3-8H,1-2H3,(H,13,14,15)

SMILES Code

CC1=CC(C)=NC(NC2=CC=CC=C2)=N1

Appearance

Solid powder

Purity

>95% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Pyrimethanil inhibits the biosynthesis of methionine and other amino acids in Botrytis cinerea. Pyrimethanil can be used for the research of fungal diseases prevention on fruit, vegetable and ornamental plants with mold infection.

In vitro activity:

In vitro investigations were conducted to assess the activity of pyrimethanil, an anilinopyrimidine fungicide, against Penicillium digitatum, a common citrus fruit pathogen. Pyrimethanil at 0.20 μg/ml reduced methionine production in mycelia and inhibited the activity of cell wall-degrading enzymes, such as cellulase and pectinase. Reference: Plant Dis. 2021 Jun;105(6):1758-1764. https://pubmed.ncbi.nlm.nih.gov/33044143/

In vivo activity:

This study investigated the effectiveness of pyrimethanil as a postharvest fungicide against green and blue molds caused by Penicillium digitatum and Penicillium italicum, respectively. Pyrimethanil treatments, especially at higher temperatures, significantly reduced mold development without adversely affecting the fruit's external appearance, flavor, or taste. Pyrimethanil is an effective option for mold control in citrus fruits. Reference: J Agric Food Chem. 2006 Jun 28;54(13):4721-6. https://pubmed.ncbi.nlm.nih.gov/16787020/

	Solvent	mg/mL	mM
Solubility
	DMSO	130.0	652.45

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 199.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Zhang Y, Fu Y, Luo C, Zhu F. Pyrimethanil Sensitivity and Resistance Mechanisms in Penicillium digitatum. Plant Dis. 2021 Jun;105(6):1758-1764. doi: 10.1094/PDIS-08-20-1739-RE. Epub 2021 Apr 22. PMID: 33044143. 2. Cus F, Raspor P. The effect of pyrimethanil on the growth of wine yeasts. Lett Appl Microbiol. 2008 Jul;47(1):54-9. doi: 10.1111/j.1472-765X.2008.02383.x. Epub 2008 Jun 9. PMID: 18544142. 3. D'Aquino S, Schirra M, Palma A, Angioni A, Cabras P, Migheli Q. Residue levels and effectiveness of pyrimethanil vs imazalil when using heated postharvest dip treatments for control of Penicillium decay on citrus fruit. J Agric Food Chem. 2006 Jun 28;54(13):4721-6. doi: 10.1021/jf0606555. PMID: 16787020.

In vitro protocol:

In vivo protocol:

1. Cus F, Raspor P. The effect of pyrimethanil on the growth of wine yeasts. Lett Appl Microbiol. 2008 Jul;47(1):54-9. doi: 10.1111/j.1472-765X.2008.02383.x. Epub 2008 Jun 9. PMID: 18544142. 2. D'Aquino S, Schirra M, Palma A, Angioni A, Cabras P, Migheli Q. Residue levels and effectiveness of pyrimethanil vs imazalil when using heated postharvest dip treatments for control of Penicillium decay on citrus fruit. J Agric Food Chem. 2006 Jun 28;54(13):4721-6. doi: 10.1021/jf0606555. PMID: 16787020.

1. Xu D, Yu G, Xi P, Kong X, Wang Q, Gao L, Jiang Z. Synergistic Effects of Resveratrol and Pyrimethanil against Botrytis cinerea on Grape. Molecules. 2018 Jun 15;23(6):1455. doi: 10.3390/molecules23061455. PMID: 29914082; PMCID: PMC6099729.