SPB5208 | PROTAC targeting BTK

MedKoo Cat#: 123555 | Name: SPB5208

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SPB5208 is a PROTAC targeting BTK.

Chemical Structure

SPB5208

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 123555

Name: SPB5208

CAS#: N/A

Chemical Formula: C44H47N7O9

Exact Mass: 817.3400

Molecular Weight: 817.90

Elemental Analysis: C, 64.61; H, 5.79; N, 11.99; O, 17.60

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

SPB5208; SPB 5208; SPB-5208

IUPAC/Chemical Name

4-(2-(2-(2-(2-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)piperidin-1-yl)ethoxy)ethoxy)ethoxy)ethoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

InChi Key

PCALLPMCBXZHIT-UHFFFAOYSA-N

InChi Code

InChI=1S/C44H47N7O9/c45-34-17-18-46-41-39(34)40(29-11-13-32(14-12-29)60-31-7-2-1-3-8-31)48-51(41)30-6-5-19-49(28-30)20-21-56-22-23-57-24-25-58-26-27-59-36-10-4-9-33-38(36)44(55)50(43(33)54)35-15-16-37(52)47-42(35)53/h1-4,7-14,17-18,30,35H,5-6,15-16,19-28H2,(H2,45,46)(H,47,52,53)

SMILES Code

O=C1NC(C(CC1)N2C(C3=C(C2=O)C(OCCOCCOCCOCCN4CCCC(N5N=C(C6=CC=C(OC7=CC=CC=C7)C=C6)C8=C5N=CC=C8N)C4)=CC=C3)=O)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 817.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1.Yu F, Cai M, Shao L, Zhang J. Targeting Protein Kinases Degradation by PROTACs. Front Chem. 2021 Jun 30;9:679120. doi: 10.3389/fchem.2021.679120. PMID: 34277564; PMCID: PMC8279777. 2. He M, Cao C, Ni Z, Liu Y, Song P, Hao S, He Y, Sun X, Rao Y. PROTACs: great opportunities for academia and industry (an update from 2020 to 2021). Signal Transduct Target Ther. 2022 Jun 9;7(1):181. doi: 10.1038/s41392-022-00999-9. PMID: 35680848; PMCID: PMC9178337.