PS77 | CAS# 1450888-35-3 | Pkh inhibitor

MedKoo Cat#: 574849 | Name: PS77

Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PS77 is a Pkh inhibitor directed to the PIF-pocket with increased selectivity for C. albicans Pkh2.

Chemical Structure

PS77

CAS#1450888-35-3

Theoretical Analysis

MedKoo Cat#: 574849

Name: PS77

CAS#: 1450888-35-3

Chemical Formula: C23H18Cl2O3S2

Exact Mass: 476.0074

Molecular Weight: 477.41

Elemental Analysis: C, 57.86; H, 3.80; Cl, 14.85; O, 10.05; S, 13.43

Price and Availability

Size	Price	Availability
5mg	USD 295.00	2 Weeks
10mg	USD 480.00	2 Weeks
25mg	USD 850.00	2 Weeks
50mg	USD 1,280.00	2 Weeks
100mg	USD 2,000.00	2 Weeks

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

No Data

Synonym

PS77; PS 77; PS-77

IUPAC/Chemical Name

{3-(4-Chloro-phenyl)-1-[2-(4-chloro-phenylsulfanyl)-phenyl]-3-oxo-propylsulfanyl}-acetic acid

InChi Key

VAULNRMHUJFUGY-UHFFFAOYSA-N

InChi Code

InChI=1S/C23H18Cl2O3S2/c24-16-7-5-15(6-8-16)20(26)13-22(29-14-23(27)28)19-3-1-2-4-21(19)30-18-11-9-17(25)10-12-18/h1-12,22H,13-14H2,(H,27,28)

SMILES Code

O=C(O)CSC(C1=CC=CC=C1SC2=CC=C(Cl)C=C2)CC(C3=CC=C(Cl)C=C3)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

PS77 is a Pkh inhibitor.

In vitro activity:

This study identified and characterized PS77, which has increased selectivity for C. albicans Pkh2.

In vivo activity:

To be determined

Preparing Stock Solutions

The following data is based on the product molecular weight 477.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

In vitro protocol:

In vivo protocol:

To be determined

1. Pastor-Flores D, Schulze JO, Bahí A, Giacometti R, Ferrer-Dalmau J, Passeron S, Engel M, Süss E, Casamayor A, Biondi RM. PIF-pocket as a target for C. albicans Pkh selective inhibitors. ACS Chem Biol. 2013 Oct 18;8(10):2283-92. doi: 10.1021/cb400452z. Epub 2013 Aug 22. PMID: 23911092. 2. Li J, Wang J, Hou W, Jing Z, Tian C, Han Y, Liao J, Dong MQ, Xu X. Phosphorylation of Ataxin-10 by polo-like kinase 1 is required for cytokinesis. Cell Cycle. 2011 Sep 1;10(17):2946-58. doi: 10.4161/cc.10.17.15922. Epub 2011 Sep 1. PMID: 21857149.