MedKoo Cat#: 574765 | Name: Kobusin
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Kobusin is a bisepoxylignan compound isolated from plants such as Zanthoxylum rhetsa and Magnoliae flos, known for its diverse biological activities. It exhibits anti-inflammatory, antiplasmodial, and cytotoxic properties, potentially beneficial in treating neuroinflammatory conditions by inhibiting inducible nitric oxide synthase (iNOS) expression and scavenging peroxynitrite radicals

Chemical Structure

Kobusin
Kobusin
CAS#36150-23-9

Theoretical Analysis

MedKoo Cat#: 574765

Name: Kobusin

CAS#: 36150-23-9

Chemical Formula: C21H22O6

Exact Mass: 370.1416

Molecular Weight: 370.40

Elemental Analysis: C, 68.10; H, 5.99; O, 25.92

Price and Availability

Size Price Availability Quantity
5mg USD 450.00 2 Weeks
10mg USD 750.00 2 Weeks
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Related CAS #
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Synonym
Kobusin
IUPAC/Chemical Name
5-(4-(3,4-dimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl)benzo[d][1,3]dioxole
InChi Key
AWOGQCSIVCQXBT-VUEDXXQZSA-N
InChi Code
InChI=1S/C21H22O6/c1-22-16-5-3-12(7-18(16)23-2)20-14-9-25-21(15(14)10-24-20)13-4-6-17-19(8-13)27-11-26-17/h3-8,14-15,20-21H,9-11H2,1-2H3/t14-,15-,20+,21+/m0/s1
SMILES Code
COC1=C(C=C(C=C1)C2C3COC(C3CO2)C4=CC5=C(C=C4)OCO5)OC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Biological target:
Kobusin is an activator of CFTR and CaCCgie chloride channels and a inhibitor of ANO1/CaCC (calcium-activated chloride channel) channel.
In vitro activity:
Remarkably, the compounds showed inhibitory effects toward ANO1/CaCC-mediated short-circuit currents in ANO1/CaCC-expressing FRT cells, with IC50 values of 100 μM for kobusin and 200 μM for eudesmin. Reference: Front Plant Sci. 2015 Nov 25;6:1041. https://pubmed.ncbi.nlm.nih.gov/26635857/
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 370.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Jiang Y, Yu B, Fang F, Cao H, Ma T, Yang H. Modulation of Chloride Channel Functions by the Plant Lignan Compounds Kobusin and Eudesmin. Front Plant Sci. 2015 Nov 25;6:1041. doi: 10.3389/fpls.2015.01041. PMID: 26635857; PMCID: PMC4658577.
In vitro protocol:
1. Jiang Y, Yu B, Fang F, Cao H, Ma T, Yang H. Modulation of Chloride Channel Functions by the Plant Lignan Compounds Kobusin and Eudesmin. Front Plant Sci. 2015 Nov 25;6:1041. doi: 10.3389/fpls.2015.01041. PMID: 26635857; PMCID: PMC4658577.
In vivo protocol:
TBD
1. Jiang Y, Yu B, Fang F, Cao H, Ma T, Yang H. Modulation of Chloride Channel Functions by the Plant Lignan Compounds Kobusin and Eudesmin. Front Plant Sci. 2015;6:1041. Published 2015 Nov 25. doi:10.3389/fpls.2015.01041