KNT-127 | CAS#1256921-89-7 | δ-Opioid receptor agonist

MedKoo Cat#: 563292 | Name: KNT-127

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KNT-127 is a δ-Opioid receptor agonist.

Chemical Structure

KNT-127

CAS#1256921-89-7

Theoretical Analysis

MedKoo Cat#: 563292

Name: KNT-127

CAS#: 1256921-89-7

Chemical Formula: C24H24N2O2

Exact Mass: 372.1838

Molecular Weight: 372.46

Elemental Analysis: C, 77.39; H, 6.50; N, 7.52; O, 8.59

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

KNT-127; KNT 127; KNT127;

IUPAC/Chemical Name

(6R,6aS,14aR)-17-methyl-5,6,7,14-tetrahydro-6aH-6,14a-(epiminoethano)naphtho[2,1-b]acridine-2,6a-diol

InChi Key

NFXFNBIPWUYEIM-WXFUMESZSA-N

InChi Code

InChI=1S/C24H24N2O2/c1-26-9-8-23-14-21-17(10-16-4-2-3-5-20(16)25-21)13-24(23,28)22(26)11-15-6-7-18(27)12-19(15)23/h2-7,10,12,22,27-28H,8-9,11,13-14H2,1H3/t22-,23-,24-/m1/s1

SMILES Code

OC1=CC2=C(C=C1)C[C@]3([H])[C@]4(O)CC5=CC6=CC=CC=C6N=C5C[C@@]42CCN3C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 372.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Saitoh A, Tominaga H, Ogawa Y, Irukayama-Tomobe Y, Yamada M, Yanagisawa M, Nagase H. Effects of the delta opioid receptor agonist KNT-127 on electroencephalographic activity in mice. Pharmacol Rep. 2018 Apr;70(2):350-354. doi: 10.1016/j.pharep.2017.08.018. Epub 2017 Oct 28. PubMed PMID: 29477045. 2: Saitoh A, Suzuki S, Soda A, Ohashi M, Yamada M, Oka JI, Nagase H, Yamada M. The delta opioid receptor agonist KNT-127 in the prelimbic medial prefrontal cortex attenuates veratrine-induced anxiety-like behaviors in mice. Behav Brain Res. 2018 Jan 15;336:77-84. doi: 10.1016/j.bbr.2017.08.041. Epub 2017 Aug 31. PubMed PMID: 28864205. 3: Gotoh L, Saitoh A, Yamada M, Fujii H, Nagase H, Yamada M. Effects of repeated treatment with a delta opioid receptor agonist KNT-127 on hyperemotionality in olfactory-bulbectomized rats. Behav Brain Res. 2017 Apr 14;323:11-14. doi: 10.1016/j.bbr.2016.11.008. Epub 2016 Dec 1. PubMed PMID: 27916688. 4: Saitoh A, Nagase H. Delta Opioid Receptor (DOR) Ligands and Pharmacology: Development of Indolo- and Quinolinomorphinan Derivatives Based on the Message-Address Concept. Handb Exp Pharmacol. 2016 Oct 28. doi: 10.1007/164_2016_18. [Epub ahead of print] PubMed PMID: 27787711. 5: Ikeda H, Ardianto C, Yonemochi N, Yang L, Ohashi T, Ikegami M, Nagase H, Kamei J. Inhibition of opioid systems in the hypothalamus as well as the mesolimbic area suppresses feeding behavior of mice. Neuroscience. 2015 Dec 17;311:9-21. doi: 10.1016/j.neuroscience.2015.10.002. Epub 2015 Oct 24. PubMed PMID: 26454026. 6: Nozaki C, Nagase H, Nemoto T, Matifas A, Kieffer BL, Gaveriaux-Ruff C. In vivo properties of KNT-127, a novel δ opioid receptor agonist: receptor internalization, antihyperalgesia and antidepressant effects in mice. Br J Pharmacol. 2014 Dec;171(23):5376-86. doi: 10.1111/bph.12852. PubMed PMID: 25048778; PubMed Central PMCID: PMC4294046. 7: Sugiyama A, Nagase H, Oka J, Yamada M, Saitoh A. DOR(2)-selective but not DOR(1)-selective antagonist abolishes anxiolytic-like effects of the δ opioid receptor agonist KNT-127. Neuropharmacology. 2014 Apr;79:314-20. doi: 10.1016/j.neuropharm.2013.11.021. Epub 2013 Dec 12. PubMed PMID: 24333676. 8: Nemoto T, Ida Y, Iihara Y, Nakajima R, Hirayama S, Iwai T, Fujii H, Nagase H. The most effective influence of 17-(3-ethoxypropyl) substituent on the binding affinity and the agonistic activity in KNT-127 derivatives, δ opioid receptor agonists. Bioorg Med Chem. 2013 Dec 15;21(24):7628-47. doi: 10.1016/j.bmc.2013.10.032. Epub 2013 Oct 31. PubMed PMID: 24262888. 9: Saitoh A, Yamada M. Antidepressant-like Effects of δ Opioid Receptor Agonists in Animal Models. Curr Neuropharmacol. 2012 Sep;10(3):231-8. doi: 10.2174/157015912803217314. PubMed PMID: 23449756; PubMed Central PMCID: PMC3468877. 10: Saitoh A, Sugiyama A, Yamada M, Inagaki M, Oka J, Nagase H, Yamada M. The novel δ opioid receptor agonist KNT-127 produces distinct anxiolytic-like effects in rats without producing the adverse effects associated with benzodiazepines. Neuropharmacology. 2013 Apr;67:485-93. doi: 10.1016/j.neuropharm.2012.11.025. Epub 2012 Dec 14. PubMed PMID: 23246531. 11: Ida Y, Matsubara A, Nemoto T, Saito M, Hirayama S, Fujii H, Nagase H. Synthesis of quinolinomorphinan derivatives as highly selective δ opioid receptor ligands. Bioorg Med Chem. 2012 Oct 1;20(19):5810-31. doi: 10.1016/j.bmc.2012.08.004. Epub 2012 Aug 11. PubMed PMID: 22967810. 12: Tanahashi S, Ueda Y, Nakajima A, Yamamura S, Nagase H, Okada M. Novel δ1-receptor agonist KNT-127 increases the release of dopamine and L-glutamate in the striatum, nucleus accumbens and median pre-frontal cortex. Neuropharmacology. 2012 Apr;62(5-6):2057-67. doi: 10.1016/j.neuropharm.2012.01.005. Epub 2012 Jan 17. PubMed PMID: 22266218. 13: Saitoh A, Sugiyama A, Nemoto T, Fujii H, Wada K, Oka J, Nagase H, Yamada M. The novel δ opioid receptor agonist KNT-127 produces antidepressant-like and antinociceptive effects in mice without producing convulsions. Behav Brain Res. 2011 Oct 1;223(2):271-9. doi: 10.1016/j.bbr.2011.04.041. Epub 2011 May 5. PubMed PMID: 21565223. 14: Nagase H, Nemoto T, Matsubara A, Saito M, Yamamoto N, Osa Y, Hirayama S, Nakajima M, Nakao K, Mochizuki H, Fujii H. Design and synthesis of KNT-127, a δ-opioid receptor agonist effective by systemic administration. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6302-5. doi: 10.1016/j.bmcl.2010.08.083. Epub 2010 Aug 21. PubMed PMID: 20850307.