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MedKoo Cat#: 463053 | Name: Dimetofrine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dimetofrine is a cardiac stimulant. It was investigated as a treatment for orthostatic hypotension.

Chemical Structure

Dimetofrine
CAS#22950-29-4

Theoretical Analysis

MedKoo Cat#: 463053

Name: Dimetofrine

CAS#: 22950-29-4

Chemical Formula: C11H17NO4

Exact Mass: 227.1158

Molecular Weight: 227.26

Elemental Analysis: C, 58.14; H, 7.54; N, 6.16; O, 28.16

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Dimetofrine; Dimethophrine; Anassicol; Dimetofrina; Dimetofrinum;
IUPAC/Chemical Name
4-(1-hydroxy-2-(methylamino)ethyl)-2,6-dimethoxyphenol
InChi Key
ZKGDBJAHIIXDDW-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H17NO4/c1-12-6-8(13)7-4-9(15-2)11(14)10(5-7)16-3/h4-5,8,12-14H,6H2,1-3H3
SMILES Code
CNCC(c1cc(OC)c(O)c(OC)c1)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 227.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: McClellan KJ, Wiseman LR, Wilde MI. Midodrine. A review of its therapeutic use in the management of orthostatic hypotension. Drugs Aging. 1998 Jan;12(1):76-86. doi: 10.2165/00002512-199812010-00007. PMID: 9467688. 2: Royal MC, Mariano D. Lending a drug in short supply. Am J Hosp Pharm. 1994 Apr 15;51(8):1025; discussion 1025-9. PMID: 8037221. 3: McTavish D, Goa KL. Midodrine. A review of its pharmacological properties and therapeutic use in orthostatic hypotension and secondary hypotensive disorders. Drugs. 1989 Nov;38(5):757-77. doi: 10.2165/00003495-198938050-00004. Erratum in: Drugs 1990 Feb;39(2):followi. PMID: 2480881. 4: Mazzei M, Roma G, Balbi A, Sottofattori E, Robbiano L. Formation of 2,6-dimethoxy-1,4-benzoquinone, a highly genotoxic compound, from the reaction of sodium nitrite with the sympathomimetic drug dimethophrine in acidic aqueous solution. Farmaco Sci. 1988 Jun;43(6):523-38. PMID: 3208895. 5: Brambilla G, Robbiano L, Cajelli E, Martelli A, Turmolini F, Mazzei M. Cytotoxic, DNA-damaging and mutagenic properties of 2,6-dimethoxy-1,4-benzoquinone, formed by dimethophrine-nitrite interaction. J Pharmacol Exp Ther. 1988 Mar;244(3):1011-5. PMID: 3252018. 6: Canonero R, Poggi C. Attivita' mutagena del 2,6-dimetossi-1,4-benzochinone, prodotto dalla nitrosazione della dimetofrina, in cellule V 79 [Mutagenic activity of 2,6-dimethoxy-1,4-benzoquinone, produced during the nitrosation of dimethophrine, in V 79 cells]. Boll Soc Ital Biol Sper. 1988 Jan;64(1):61-8. Italian. PMID: 3166781. 7: Marsoni V. Effective treatment of post-partum hypotension with dimetophrine: a placebo-controlled, double-blind trial. Curr Med Res Opin. 1985;9(8):578-85. doi: 10.1185/03007998509109637. PMID: 3896665. 8: Baldrighi V, Aiazzi L, Castelli C, Seveso G. Double-blind clinical evaluation of dimetophrine in chronically reduced arterial tension. Curr Med Res Opin. 1984;9(2):78-85. doi: 10.1185/03007998409109563. PMID: 6399891. 9: Marini U, Cecchi A, Venturini M. Controlled clinical investigation of dimetophrine versus midodrine in the management of moderately decreased arterial blood pressure. Curr Med Res Opin. 1984;9(4):265-74. doi: 10.1185/03007998409109590. PMID: 6210180. 10: Stramba-Badiale M, Scillieri E, Castoldi C. La prova di funzionalità cardiocircolatoria con 1-(3,5-dimetossi-4-idrossifenil)-2-monometilaminoetanolo cloridrato: una modificazione della prova di Rehn [Cardiocirculatory function test with 1-(3,5-dimethoxy-4-hydroxyphenyl)-2-monomethylaminoethanol hydrochloride: a modification of the Rehn test]. Clin Ter. 1981 Mar 31;96(6):643-6. Italian. PMID: 6456863. 11: Ieri A, Zipoli A, Ciattini S. Tachicardia sopraventricolare iatrogena nel neonato per assorbimento di dimetofrina dal latte materno [Iatrogenic supraventricular tachycardia in a newborn infant caused by absorption of dimethophrine from the mother's milk]. Cardiol Prat. 1978 Jan-Jun;29(1):17-21. Italian. PMID: 570884. 12: Boselli P, Basagni M. Cinetica della dimetofrina: studio di un modello multicompartimentale [Kinetics of dimethophrine: study on a multicompartimental model]. Farmaco Sci. 1977 Mar;32(3):205-11. Italian. PMID: 558115. 13: Benedetti MS, Larue DA, Perrier CV, Sitavanc L. Pharmacokinetic and metabolic pathways of dimethophrine in man. Arzneimittelforschung. 1977;27(1):158-61. PMID: 576818. 14: Cuccurullo F, Abate G, Tomassetti V, Curti A, Mezzetti A, Masi M, Rosini R. Studio emodinamico nell'animale e nell'uomo di una nuova amina simpaticomimetica: la dimetofrina [Hemodynamic study in animals and man on a new sympathomimetic amine: dimethophrine]. Clin Ter. 1976 Nov 30;79(4):347-60. Italian. PMID: 1035147. 15: Boselli P, Gervasi GB, Scrollini F. Serum kinetics and urinary metabolism of dimethophrine in rat. Arzneimittelforschung. 1976;26(11):2038-9. PMID: 1037241. 16: Pantarotto C, Belvedere G, Frigerio A. Gas chromatographic determination of dimethophrine in biological specimens of rabbit. Arzneimittelforschung. 1976;26(10):1857-60. PMID: 1037205. 17: Cortinovis A, Crippa A, Sommo F. Modificazioni emodinamiche indotte da una amina simpaticomimetica: la dimetofrina [Hemodynamic changes induced with a sympathomimetic amine: dimethophrine]. Minerva Cardioangiol. 1975 Jun- Jul;23(6-7):403-5. Italian. PMID: 1170524. 18: Romano A, Scrollini F, Ribera P, Monguzzi G. Specificita recettoriale della dimetofrina [Receptor specificity of dimethophrine]. Farmaco Prat. 1974 Nov;29(11):665-70. Italian. PMID: 4435206. 19: Romano A, Caliari S, Monguzzi G. Effetti della dimetofrina sul ritmo cardiaco del coniglio anestetizzato con cloroformio o con fluotano [Effects of dimethophrine on the heart rhythm of the rabbit anesthetized with chloroform and fluothane]. Boll Chim Farm. 1974 Jul;113(7):392-6. Italian. PMID: 4433423. 20: Tartara A, Savoldi F, Mazzella GL, Lombardi M. Rilievi elettroencefalografici nel coniglio sull'azione centrale di un'amina simpaticomimetica di sintesi (dimetofrina) [Electroencephalographic findings in the rabbit on the central action of a synthetic sympathomimetic amine (dimethophrine)]. Farmaco Prat. 1974 May;29(5):238-42. Italian. PMID: 4846080.