Synonym
Merodantoin; compound C1;
IUPAC/Chemical Name
1,3-Dibutyl-2-thiooxo-imidazolidine-4,5-dione
InChi Key
XUHLNLNNPFTDLA-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H18N2O2S/c1-3-5-7-12-9(14)10(15)13(11(12)16)8-6-4-2/h3-8H2,1-2H3
SMILES Code
O=C(C(N1CCCC)=O)N(CCCC)C1=S
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
|
Solvent |
mg/mL |
mM |
comments |
| Solubility |
| Soluble in DMSO |
0.0 |
100.00 |
|
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
242.34
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Iskandar K, Rezlan M, Yadav SK, Foo CH, Sethi G, Qiang Y, Bellot GL, Pervaiz S. Synthetic Lethality of a Novel Small Molecule Against Mutant KRAS-Expressing Cancer Cells Involves AKT-Dependent ROS Production. Antioxid Redox Signal. 2016 May 10;24(14):781-94. doi: 10.1089/ars.2015.6362. Epub 2016 Feb 26. PubMed PMID: 26714745.
2: Gulliya KS, Sharma R, Liu HW, Arnold L, Matthews JL. Relationship of mitochondrial function and cellular adenosine triphosphate levels to pMC540 and merodantoin cytotoxicity in MCF-7 human breast cancer cells. Anticancer Drugs. 1995 Aug;6(4):545-52. PubMed PMID: 7579558.
3: Sharma R, Arnold L, Gulliya KS. Correlation between DNA topoisomerase II activity and cytotoxicity in pMC540 and merodantoin sensitive and resistant human breast cancer cells. Anticancer Res. 1995 Mar-Apr;15(2):295-304. PubMed PMID: 7762997.
4: Sharma R, Gulliya KS. Growth inhibitory effects of pMC540 and merodantoin on established MCF-7 human breast tumor xenografts. In Vivo. 1995 Mar-Apr;9(2):103-8. PubMed PMID: 7548784.
5: Gulliya KS, Franck B, Schneider U, Sharma R, Arnold L, Matthews JL. Topoisomerase II-dependent novel antitumor compounds merocil and merodantoin induce apoptosis in Daudi cells. Anticancer Drugs. 1994 Oct;5(5):557-66. PubMed PMID: 7858288.
6: Gulliya KS, Sharma RK, Matthews JL, Benniston AC, Harriman A, Nemunaitis JJ. In vitro and in vivo growth suppression of MCF-7 human breast cancer by novel photoproducts and tamoxifen. Cancer. 1994 Sep 15;74(6):1725-32. PubMed PMID: 8082074.
