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MedKoo Cat#: 574786 | Name: Minozac dihydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Minozac dihydrochloride has been shown to suppress brain proinflammatory cytokine up-regulation.

Chemical Structure

Minozac dihydrochloride
Minozac dihydrochloride
CAS#924909-75-1 (2HCl)

Theoretical Analysis

MedKoo Cat#: 574786

Name: Minozac dihydrochloride

CAS#: 924909-75-1 (2HCl)

Chemical Formula: C19H22Cl2N6

Exact Mass: 404.1283

Molecular Weight: 405.33

Elemental Analysis: C, 56.30; H, 5.47; Cl, 17.49; N, 20.73

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
886208-65-7 (free base) 924909-75-1 (2HCl)
Synonym
Minozac dihydrochloride; Minozac 2HCl
IUPAC/Chemical Name
4-methyl-6-phenyl-3-(4-pyrimidin-2-ylpiperazin-1-yl)pyridazine;dihydrochloride
InChi Key
CSGQAXNJZHDONX-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H20N6.2ClH/c1-15-14-17(16-6-3-2-4-7-16)22-23-18(15)24-10-12-25(13-11-24)19-20-8-5-9-21-19;;/h2-9,14H,10-13H2,1H3;2*1H
SMILES Code
CC1=CC(C2=CC=CC=C2)=NN=C1N3CCN(C4=NC=CC=N4)CC3.[H]Cl.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 405.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Chrzaszcz M, Venkatesan C, Dragisic T, Watterson DM, Wainwright MS. Minozac treatment prevents increased seizure susceptibility in a mouse "two-hit" model of closed skull traumatic brain injury and electroconvulsive shock-induced seizures. J Neurotrauma. 2010;27(7):1283-1295. doi:10.1089/neu.2009.1227 2. Lloyd E, Somera-Molina K, Van Eldik LJ, Watterson DM, Wainwright MS. Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury. J Neuroinflammation. 2008;5:28. Published 2008 Jun 30. doi:10.1186/1742-2094-5-28