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MedKoo Cat#: 526498 | Name: Zolantidine dimaleate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Zolantidine dimaleate is a potent, selective, and brain penetrating H2 receptor antagonist.

Chemical Structure

Zolantidine dimaleate
Zolantidine dimaleate
CAS#104076-39-3

Theoretical Analysis

MedKoo Cat#: 526498

Name: Zolantidine dimaleate

CAS#: 104076-39-3

Chemical Formula: C30H35N3O9S

Exact Mass: 613.2100

Molecular Weight: 613.68

Elemental Analysis: C, 58.72; H, 5.75; N, 6.85; O, 23.46; S, 5.22

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Zolantidine dimaleate
IUPAC/Chemical Name
N-[3-[3-(Piperidin-1-ylmethyl)phenoxy]propyl]-1,3-benzothiazol-2-amine dimaleate salt
InChi Key
IECBEVAUEBZJCF-SPIKMXEPSA-N
InChi Code
InChI=1S/C22H27N3OS.2C4H4O4/c1-4-13-25(14-5-1)17-18-8-6-9-19(16-18)26-15-7-12-23-22-24-20-10-2-3-11-21(20)27-22;2*5-3(6)1-2-4(7)8/h2-3,6,8-11,16H,1,4-5,7,12-15,17H2,(H,23,24);2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-
SMILES Code
O=C(O)/C=C\C(O)=O.O=C(O)/C=C\C(O)=O.C1(NCCCOC2=CC=CC(CN3CCCCC3)=C2)=NC4=CC=CC=C4S1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 613.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hough LB, Nalwalk JW. Inhibition of morphine antinociception by centrally administered histamine H2 receptor antagonists. Eur J Pharmacol. 1992 Apr 29;215(1):69-74. PubMed PMID: 1355443. 2: Hough LB, Nalwalk JW, Battles AH. Zolantidine-induced attenuation of morphine antinociception in rhesus monkeys. Brain Res. 1990 Aug 27;526(1):153-5. PubMed PMID: 1981852. 3: Gogas KR, Hough LB, Eberle NB, Lyon RA, Glick SD, Ward SJ, Young RC, Parsons ME. A role for histamine and H2-receptors in opioid antinociception. J Pharmacol Exp Ther. 1989 Aug;250(2):476-84. PubMed PMID: 2547933. 4: Gogas KR, Hough LB. Inhibition of naloxone-resistant antinociception by centrally administered H2-antagonists. J Pharmacol Exp Ther. 1989 Jan;248(1):262-7. PubMed PMID: 2563290. 5: Hough LB, Jackowski S, Eberle N, Gogas KR, Camarota NA, Cue D. Actions of the brain-penetrating H2-antagonist zolantidine on histamine dynamics and metabolism in rat brain. Biochem Pharmacol. 1988 Dec 15;37(24):4707-11. PubMed PMID: 3202904.