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MedKoo Cat#: 522661 | Name: TUG-424

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TUG-424 is a a potent and selective free fatty acid receptor 1 agonist. TUG-424 significantly increased glucose-stimulated insulin secretion at 100 nM and may serve to explore the role of FFA1 in metabolic diseases such as diabetes or obesity. It enhanced glucose-stimulated insulin secretion in a rat beta-cell line already at 100 nM and from isolated mouse islets through FFA1.

Chemical Structure

TUG-424
TUG-424
CAS#1082058-99-8

Theoretical Analysis

MedKoo Cat#: 522661

Name: TUG-424

CAS#: 1082058-99-8

Chemical Formula: C18H16O2

Exact Mass: 264.1150

Molecular Weight: 264.32

Elemental Analysis: C, 81.79; H, 6.10; O, 12.11

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
TUG-424; TUG424; TUG 424.
IUPAC/Chemical Name
3-(4-(o-tolylethynyl)phenyl)propanoic acid
InChi Key
InChi Code
SMILES Code
O=C(O)CCC1=CC=C(C#CC2=CC=CC=C2C)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 264.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hagesaether E, Christiansen E, Due-Hansen ME, Ulven T. Mucus can change the permeation rank order of drug candidates. Int J Pharm. 2013 Aug 16;452(1-2):276-82. doi: 10.1016/j.ijpharm.2013.05.036. Epub 2013 May 23. PubMed PMID: 23707884. 2: Christiansen E, Due-Hansen ME, Urban C, Grundmann M, Schmidt J, Hansen SV, Hudson BD, Zaibi M, Markussen SB, Hagesaether E, Milligan G, Cawthorne MA, Kostenis E, Kassack MU, Ulven T. Discovery of a potent and selective free fatty acid receptor 1 agonist with low lipophilicity and high oral bioavailability. J Med Chem. 2013 Feb 14;56(3):982-92. doi: 10.1021/jm301470a. Epub 2013 Jan 22. PubMed PMID: 23294321. 3: Christiansen E, Urban C, Merten N, Liebscher K, Karlsen KK, Hamacher A, Spinrath A, Bond AD, Drewke C, Ullrich S, Kassack MU, Kostenis E, Ulven T. Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA(1)/GPR40), a potential target for the treatment of type II diabetes. J Med Chem. 2008 Nov 27;51(22):7061-4. doi: 10.1021/jm8010178. PubMed PMID: 18947221.