LCS-1 | CAS# 41931-13-9 | SOD1 inhibitor

MedKoo Cat#: 574768 | Name: LCS-1

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

LCS-1 is a superoxide dismutase 1 (SOD1) inhibitor that has been shown to prevent serum-induced activation of the ERK and PI 3-kinase/AKT signaling pathways.

Chemical Structure

LCS-1

CAS#41931-13-9

Theoretical Analysis

MedKoo Cat#: 574768

Name: LCS-1

CAS#: 41931-13-9

Chemical Formula: C11H8Cl2N2O

Exact Mass: 254.0014

Molecular Weight: 255.10

Elemental Analysis: C, 51.79; H, 3.16; Cl, 27.79; N, 10.98; O, 6.27

Price and Availability

Size	Price	Availability	Quantity
10mg	USD 295.00	2 Weeks
50mg	USD 775.00	2 Weeks

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Related CAS #

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Synonym

LCS-1, LCS1, LCS 1

IUPAC/Chemical Name

4,5-dichloro-2-m-tolylpyridazin-3(2H)-one

InChi Key

SYUPLLHVMCLXEM-UHFFFAOYSA-N

InChi Code

InChI=1S/C11H8Cl2N2O/c1-7-3-2-4-8(5-7)15-11(16)10(13)9(12)6-14-15/h2-6H,1H3

SMILES Code

O=C1C(Cl)=C(Cl)C=NN1C2=CC=CC(C)=C2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

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Product Data

Product Data

Instruction

View handling instruction

Biological target:

LCS-1 is a superoxide dismutase 1 (SOD1) inhibitor.

In vitro activity:

siRNAs against SOD1 slowed the growth of LCS-1 sensitive cell lines; conversely, expression of a SOD1 cDNA increased proliferation of H358 cells and reduced sensitivity of these cells to LCS-1. Reference: Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16375-80. https://pubmed.ncbi.nlm.nih.gov/21930909/

In vivo activity:

Furthermore, LCS-1 decreased the growth of xenograft tumors formed by U87 glioma cells in nude mice. Reference: Front Oncol. 2022 Aug 1;12:937444. https://pubmed.ncbi.nlm.nih.gov/35978820/

	Solvent	mg/mL	mM
Solubility
	DMF	2.0	7.84
	DMSO	34.7	135.90
	Ethanol	6.0	23.52

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 255.10 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Ling M, Liu Q, Wang Y, Liu X, Jiang M, Hu J. LCS-1 inhibition of superoxide dismutase 1 induces ROS-dependent death of glioma cells and degradates PARP and BRCA1. Front Oncol. 2022 Aug 1;12:937444. doi: 10.3389/fonc.2022.937444. PMID: 35978820; PMCID: PMC9376264. 2. Somwar R, Erdjument-Bromage H, Larsson E, Shum D, Lockwood WW, Yang G, Sander C, Ouerfelli O, Tempst PJ, Djaballah H, Varmus HE. Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines. Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16375-80. doi: 10.1073/pnas.1113554108. Epub 2011 Sep 19. PMID: 21930909; PMCID: PMC3182729. 3. Du T, Song Y, Ray A, Chauhan D, Anderson KC. Proteomic analysis identifies mechanism(s) of overcoming bortezomib resistance via targeting ubiquitin receptor Rpn13. Leukemia. 2021 Feb;35(2):550-561. doi: 10.1038/s41375-020-0865-2. Epub 2020 May 18. PMID: 32424294; PMCID: PMC7988682.

In vitro protocol:

In vivo protocol:

1. R. Somwar et al. Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines. PNAS 2011, 108, 16375-16380.