HLI-373 is an inhibitor of Hdm2 ubiquitin ligase (E3) that blocks Hdm2-mediated ubiquitylation and proteasomal degradation of p53. HLI-373 induces apoptosis in several tumor cell lines that express wild-type p53 such as LOX-IMVI, A549, HT1080 and U2OS.
MedKoo Cat#: 574729
Name: HLI-373 dihydrochloride
CAS#: 1782531-99-0(HCl)
Chemical Formula: C18H25Cl2N5O2
Exact Mass: 413.1385
Molecular Weight: 414.33
Elemental Analysis: C, 52.18; H, 6.08; Cl, 17.11; N, 16.90; O, 7.72
The following data is based on the product molecular weight 414.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
