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MedKoo Cat#: 462829 | Name: LY 2886721 Hydrochloride
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

LY 2886721 Hydrochloride is a potent and selective β-secretase inhibitor.

Chemical Structure

LY 2886721 Hydrochloride
LY 2886721 Hydrochloride
CAS#1262036-49-6 (HCl )

Theoretical Analysis

MedKoo Cat#: 462829

Name: LY 2886721 Hydrochloride

CAS#: 1262036-49-6 (HCl )

Chemical Formula: C18H17ClF2N4O2S

Exact Mass: 426.0729

Molecular Weight: 426.87

Elemental Analysis: C, 50.65; H, 4.01; Cl, 8.30; F, 8.90; N, 13.13; O, 7.50; S, 7.51

Price and Availability

Size Price Availability Quantity
25mg USD 350.00 2 Weeks
50mg USD 650.00 2 Weeks
100mg USD 1,150.00 2 Weeks
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Related CAS #
1262036-50-9 (free base) 1262036-49-6 (HCl )
Synonym
LY 2886721 Hydrochloride; LY2886721 Hydrochloride; LY-2886721 Hydrochloride; LY2886721 HCl; LY 2886721 HCl; LY-2886721 HCl;
IUPAC/Chemical Name
N-(3-((4aS,7aS)-2-amino-4a,5-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(7H)-yl)-4-fluorophenyl)-5-fluoropicolinamide hydrochloride
InChi Key
JHHMCINLHBUFHB-GHDSXOKHSA-N
InChi Code
InChI=1S/C18H16F2N4O2S.ClH/c19-11-1-4-15(22-6-11)16(25)23-12-2-3-14(20)13(5-12)18-9-26-7-10(18)8-27-17(21)24-18;/h1-6,10H,7-9H2,(H2,21,24)(H,23,25);1H/t10-,18-;/m0./s1
SMILES Code
[H][C@@]12COC[C@@]1(N=C(N)SC2)C3=CC(NC(C4=CC=C(F)C=N4)=O)=CC=C3F.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
LY 2886721 Hydrochloride is a potent and selective β-secretase inhibitor.
In vitro activity:
TBD
In vivo activity:
LY2886721 treatment improved glucose homeostasis and hepatic gluconeogenesis in diabetic PLB4 mice, as determined by improvements in basal glucose and glucose/pyruvate tolerance tests. Furthermore, LY2886721 improved hepatic insulin sensitivity, as indicated by enhanced basal hyperphosphorylation of insulin receptors. Reference: Biochim Biophys Acta Mol Basis Dis. 2021 Jul 1;1867(7):166149. https://pubmed.ncbi.nlm.nih.gov/33892080/
Solvent mg/mL mM
Solubility
DMSO 42.7 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 426.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Dekeryte R, Franklin Z, Hull C, Croce L, Kamli-Salino S, Helk O, Hoffmann PA, Yang Z, Riedel G, Delibegovic M, Platt B. The BACE1 inhibitor LY2886721 improves diabetic phenotypes of BACE1 knock-in mice. Biochim Biophys Acta Mol Basis Dis. 2021 Jul 1;1867(7):166149. doi: 10.1016/j.bbadis.2021.166149. Epub 2021 Apr 20. PMID: 33892080. 2. Takano A, Chen L, Nag S, Brodney MA, Arakawa R, Chang C, Amini N, Doran SD, Dutra JK, McCarthy TJ, Nolan CE, O'Neill BT, Villalobos A, Zhang L, Halldin C. Quantitative Analysis of 18F-PF-06684511, a Novel PET Radioligand for Selective β-Secretase 1 Imaging, in Nonhuman Primate Brain. J Nucl Med. 2019 Jul;60(7):992-997. doi: 10.2967/jnumed.118.217372. Epub 2018 Dec 7. PMID: 30530832.
In vitro protocol:
TBD
In vivo protocol:
1. Dekeryte R, Franklin Z, Hull C, Croce L, Kamli-Salino S, Helk O, Hoffmann PA, Yang Z, Riedel G, Delibegovic M, Platt B. The BACE1 inhibitor LY2886721 improves diabetic phenotypes of BACE1 knock-in mice. Biochim Biophys Acta Mol Basis Dis. 2021 Jul 1;1867(7):166149. doi: 10.1016/j.bbadis.2021.166149. Epub 2021 Apr 20. PMID: 33892080. 2. Takano A, Chen L, Nag S, Brodney MA, Arakawa R, Chang C, Amini N, Doran SD, Dutra JK, McCarthy TJ, Nolan CE, O'Neill BT, Villalobos A, Zhang L, Halldin C. Quantitative Analysis of 18F-PF-06684511, a Novel PET Radioligand for Selective β-Secretase 1 Imaging, in Nonhuman Primate Brain. J Nucl Med. 2019 Jul;60(7):992-997. doi: 10.2967/jnumed.118.217372. Epub 2018 Dec 7. PMID: 30530832.

View History

DAW-22

DAW-22

HU-243

HU-243