Cyclic HPMPC dihydrate | CAS# 849177-08-8 | Biochemical

MedKoo Cat#: 576006 | Name: Cyclic HPMPC dihydrate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cyclic HPMPC dihydrate is a prodrug for HPMPC.

Chemical Structure

Cyclic HPMPC dihydrate

CAS#849177-08-8

Theoretical Analysis

MedKoo Cat#: 576006

Name: Cyclic HPMPC dihydrate

CAS#: 849177-08-8

Chemical Formula: C8H16N3O7P

Exact Mass: 297.0726

Molecular Weight: 297.20

Elemental Analysis: C, 32.33; H, 5.43; N, 14.14; O, 37.68; P, 10.42

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Cyclic HPMPC dihydrate; Cyclic cidofovir dihydrate; GS 0930 dihydrate; GS0930 dihydrate; GS-0930 dihydrate

IUPAC/Chemical Name

4-Amino-1-((2-hydroxy-1,4,2-dioxaphosphorinan-5-yl)methyl)-2(1H)-pyrimidinone, p-oxide (S) dihydrate

InChi Key

RVBOXKBZYVVZJW-ILKKLZGPSA-N

InChi Code

InChI=1S/C8H12N3O5P.2H2O/c9-7-1-2-11(8(12)10-7)3-6-4-16-17(13,14)5-15-6;;/h1-2,6H,3-5H2,(H,13,14)(H2,9,10,12);2*1H2/t6-;;/m0../s1

SMILES Code

O.O.NC1=NC(=O)N(C[C@H]2COP(=O)(O)CO2)C=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

	Solvent	mg/mL	mM
Solubility
	Soluble in DMSO	0.0	100.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 297.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Cundy KC, Bidgood AM, Lynch G, Shaw JP, Griffin L, Lee WA. Pharmacokinetics, bioavailability, metabolism, and tissue distribution of cidofovir (HPMPC) and cyclic HPMPC in rats. Drug Metab Dispos. 1996 Jul;24(7):745-52. PMID: 8818571. 2: Smee DF, Bailey KW, Sidwell RW. Comparative effects of cidofovir and cyclic HPMPC on lethal cowpox and vaccinia virus respiratory infections in mice. Chemotherapy. 2003 Jun;49(3):126-31. doi: 10.1159/000070618. PMID: 12815205. 3: Oliyai R, Shaw JP, Sueoka-Lennen CM, Cundy KC, Arimilli MN, Jones RJ, Lee WA. Aryl ester prodrugs of cyclic HPMPC. I: Physicochemical characterization and in vitro biological stability. Pharm Res. 1999 Nov;16(11):1687-93. doi: 10.1023/a:1018945713623. PMID: 10571273. 4: Oliyai R, Arimilli MN, Jones RJ, Lee WA. Pharmacokinetics of salicylate ester prodrugs of cyclic HPMPC in dogs. Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):1411-4. doi: 10.1081/NCN-100002566. PMID: 11563033. 5: Cundy KC, Lynch G, Shaw JP, Hitchcock MJ, Lee WA. Distribution and metabolism of intravitreal cidofovir and cyclic HPMPC in rabbits. Curr Eye Res. 1996 May;15(5):569-76. doi: 10.3109/02713689609000768. PMID: 8670758.