MedKoo Cat#: 574684 | Name: EB-47 dihydrochloride
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

EB-47 dihydrochloride is an inhibitor of PARP-1 that reduces infarct volume in both a rat transient middle cerebral arterial occlusion model and a cardiac reperfusion model.

Chemical Structure

EB-47 dihydrochloride
EB-47 dihydrochloride
CAS#1190332-25-2 (2HCl)

Theoretical Analysis

MedKoo Cat#: 574684

Name: EB-47 dihydrochloride

CAS#: 1190332-25-2 (2HCl)

Chemical Formula: C24H29Cl2N9O6

Exact Mass: 609.1618

Molecular Weight: 610.45

Elemental Analysis: C, 47.22; H, 4.79; Cl, 11.61; N, 20.65; O, 15.73

Price and Availability

Size Price Availability Quantity
5mg USD 350.00 2 Weeks
10mg USD 600.00 2 Weeks
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Synonym
EB-47 dihydrochloride; EB-47 2HCl; EB 47 2HCl; EB47 2HCl;
IUPAC/Chemical Name
5'-Deoxy-5'-[4-[2-[(2,3-Dihydro-1-oxo-1H-isoindol-4-yl)amino]-2-oxoethyl]-1-piperazinyl]-5'-oxoadenosine dihydrochloride
InChi Key
VVMQSDIMNDTMII-MYXHFVDASA-N
InChi Code
InChI=1S/C24H27N9O6.2ClH/c25-20-16-21(28-10-27-20)33(11-29-16)24-18(36)17(35)19(39-24)23(38)32-6-4-31(5-7-32)9-15(34)30-14-3-1-2-12-13(14)8-26-22(12)37;;/h1-3,10-11,17-19,24,35-36H,4-9H2,(H,26,37)(H,30,34)(H2,25,27,28);2*1H/t17-,18+,19-,24+;;/m0../s1
SMILES Code
O[C@@H]([C@H]([C@H](N1C=NC2=C(N=CN=C21)N)O3)O)[C@H]3C(N4CCN(CC(NC5=CC=CC6=C5CNC6=O)=O)CC4)=O.[H]Cl.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 610.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Jagtap et al (2004) The discovery and synthesis of novel adenosine substituted 2,3-dihydro-1H-isoindol-1-ones: potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1). Bioorg.Med.Chem.Lett. 14 81 PMID: 14684303 2. Ferraris et al (2010) Evolution of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. From concept to clinic. J.Med.Chem. 53 4561 PMID: 20364863 3. Gaymes et al (2009) Inhibitors of poly ADP-ribose polymerase (PARP) induce apoptosis of myeloid leukemic cells: potential for therapy of myeloid leukemia and myelodysplastic syndromes. Haematologica 94 638 PMID: 19407318