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MedKoo Cat#: 462726 | Name: Tilmicosin
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tilmicosin is a semi-synthetic antibiotic.

Chemical Structure

Tilmicosin
CAS#108050-54-0 (free base)

Theoretical Analysis

MedKoo Cat#: 462726

Name: Tilmicosin

CAS#: 108050-54-0 (free base)

Chemical Formula: C46H80N2O13

Exact Mass: 868.5660

Molecular Weight: 869.15

Elemental Analysis: C, 63.57; H, 9.28; N, 3.22; O, 23.93

Price and Availability

Size Price Availability Quantity
1g USD 250.00 2 Weeks
2g USD 400.00 2 Weeks
5g USD 750.00 2 Weeks
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Related CAS #
137330-13-3 (phosphate) 108050-54-0 (free base)
Synonym
Micotil; Tilmicosine; Tilmicosinum;
IUPAC/Chemical Name
(4R,5S,6S,7R,9R,11E,13E,15R,16R)-6-(((2R,3R,4S,5S,6R)-4-(dimethylamino)-3,5-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-7-(2-((3R,5S)-3,5-dimethylpiperidin-1-yl)ethyl)-16-ethyl-4-hydroxy-15-((((2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)-5,9,13-trimethyloxacyclohexadeca-11,13-diene-2,10-dione
InChi Key
JTSDBFGMPLKDCD-XVFHVFLVSA-N
InChi Code
InChI=1S/C46H80N2O13/c1-13-36-33(24-57-46-44(56-12)43(55-11)40(53)31(8)59-46)19-25(2)14-15-34(49)28(5)20-32(16-17-48-22-26(3)18-27(4)23-48)42(29(6)35(50)21-37(51)60-36)61-45-41(54)38(47(9)10)39(52)30(7)58-45/h14-15,19,26-33,35-36,38-46,50,52-54H,13,16-18,20-24H2,1-12H3/b15-14+,25-19+/t26-,27+,28-,29+,30-,31-,32+,33-,35-,36-,38+,39-,40-,41-,42-,43-,44-,45+,46-/m1/s1
SMILES Code
CC[C@H]1OC(C[C@H]([C@@H]([C@H]([C@H](C[C@H](C(/C=C/C(C)=C/[C@@H]1CO[C@@H]2O[C@@H]([C@H]([C@H]([C@H]2OC)OC)O)C)=O)C)CCN3C[C@@H](C[C@@H](C3)C)C)O[C@@H]4O[C@@H]([C@H]([C@H](N(C)C)[C@H]4O)O)C)C)O)=O
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 869.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Xiong J, Zhu Q, Zhao Y, Yang S, Cao J, Qiu Y. Tilmicosin enteric granules and premix to pigs: Antimicrobial susceptibility testing and comparative pharmacokinetics. J Vet Pharmacol Ther. 2019 May;42(3):336-345. doi: 10.1111/jvp.12753. Epub 2019 Feb 22. PMID: 30801755. 2: Garmyn A, Vereecken M, De Gussem K, Depondt W, Haesebrouck F, Martel A. Efficacy of Tylosin and Tilmicosin Against Experimental Mycoplasma gallisepticum Infection in Chickens. Avian Dis. 2019 Jun 1;63(2):359-365. doi: 10.1637/11991-110818-Reg.1. PMID: 31251538. 3: Lemli B, Derdák D, Laczay P, Kovács D, Kunsági-Máté S. Noncovalent Interaction of Tilmicosin with Bovine Serum Albumin. Molecules. 2018 Jul 31;23(8):1915. doi: 10.3390/molecules23081915. PMID: 30065238; PMCID: PMC6222512. 4: Xiong J, Zhu Q, Yang S, Zhao Y, Cui L, Zhuang F, Qiu Y, Cao J. Comparison of pharmacokinetics of tilmicosin in healthy pigs and pigs experimentally infected with Actinobacillus pleuropneumoniae. N Z Vet J. 2019 Sep;67(5):257-263. doi: 10.1080/00480169.2019.1633434. Epub 2019 Jul 4. PMID: 31208293. 5: Martínez-Cortés I, Acevedo-Domínguez NA, Olguin-Alor R, Cortés-Hernández A, Álvarez-Jiménez V, Campillo-Navarro M, Sumano-López HS, Gutiérrez-Olvera L, Martínez-Gómez D, Maravillas-Montero JL, Loor JJ, García-Zepeda EA, Soldevila G. Tilmicosin modulates the innate immune response and preserves casein production in bovine mammary alveolar cells during Staphylococcus aureus infection. J Anim Sci. 2019 Feb 1;97(2):644-656. doi: 10.1093/jas/sky463. PMID: 30517644; PMCID: PMC6358261. 6: Huang Z, Wu Y, Zhou Z, Xia X, Gu X, Cai Q, Shen X, Yang H, Ding H. Pharmacokinetic and Pharmacodynamic Integration and Resistance Analysis of Tilmicosin Against Mycoplasma gallisepticum in an In Vitro Dynamic Model. Front Pharmacol. 2019 Jun 12;10:670. doi: 10.3389/fphar.2019.00670. PMID: 31293418; PMCID: PMC6598723. 7: Çetin E. Protective effect of ghrelin against tilmicosin-induced left ventricular dysfunction in rats. Can J Physiol Pharmacol. 2019 May;97(5):407-412. doi: 10.1139/cjpp-2018-0511. Epub 2019 Feb 6. PMID: 30726105. 8: Zhou K, Wang X, Chen D, Yuan Y, Wang S, Li C, Yan Y, Liu Q, Shao L, Huang L, Yuan Z, Xie S. Enhanced Treatment Effects of Tilmicosin Against Staphylococcus aureus Cow Mastitis by Self-Assembly Sodium Alginate- Chitosan Nanogel. Pharmaceutics. 2019 Oct 12;11(10):524. doi: 10.3390/pharmaceutics11100524. PMID: 31614726; PMCID: PMC6836059. 9: Ji X, Yang H, Wang J, Zhou W, Wang X, Qian M. Evaluation of Tilmicosin Contamination in Eggs Following Its Administration to Laying Hens and Subsequent Assessment of Dietary Risks to Chinese Consumers. J Food Sci. 2019 Oct;84(10):3054-3062. doi: 10.1111/1750-3841.14794. Epub 2019 Sep 16. PMID: 31524951. 10: Zhu L, Cao X, Xu Q, Su J, Li X, Zhou W. Evaluation of the antibacterial activity of tilmicosin-SLN against Streptococcus agalactiae: in vitro and in vivo studies. Int J Nanomedicine. 2018 Aug 17;13:4747-4755. doi: 10.2147/IJN.S168179. PMID: 30147316; PMCID: PMC6103319. 11: Dong Z, Zhou XZ, Sun JC, Meng XB, Li HS, Cheng FS, Wei XJ, Li B, Wang WW, Zhang JY. Efficacy of enteric-coated tilmicosin granules in pigs artificially infected with Actinobacillus pleuropneumoniae serotype 2. Vet Med Sci. 2020 Feb;6(1):105-113. doi: 10.1002/vms3.198. Epub 2019 Oct 7. PMID: 31589010; PMCID: PMC7036302. 12: Yang Y, Yuan L, Li J, Muhammad I, Cheng P, Xiao T, Zhang X. Preparation and evaluation of tilmicosin microspheres and lung-targeting studies in rabbits. Vet J. 2019 Apr;246:27-34. doi: 10.1016/j.tvjl.2019.01.007. Epub 2019 Feb 1. PMID: 30902186. 13: Oda SS, Derbalah AE. Impact of Diclofenac Sodium on Tilmicosin-Induced Acute Cardiotoxicity in Rats (Tilmicosin and Diclofenac Cardiotoxicity). Cardiovasc Toxicol. 2018 Feb;18(1):63-75. doi: 10.1007/s12012-017-9414-2. PMID: 28593443. 14: Zhang P, Hao H, Li J, Ahmad I, Cheng G, Chen D, Tao Y, Huang L, Wang Y, Dai M, Liu Z, Yuan Z. The Epidemiologic and Pharmacodynamic Cutoff Values of Tilmicosin against Haemophilus parasuis. Front Microbiol. 2016 Mar 22;7:385. doi: 10.3389/fmicb.2016.00385. PMID: 27047487; PMCID: PMC4802331. 15: Mohammadsadegh M. Impact of intramammary tilmicosin infusion as a dry cow therapy. J Vet Pharmacol Ther. 2018 Feb;41(1):22-27. doi: 10.1111/jvp.12427. Epub 2017 Jun 10. PMID: 28600854. 16: Huang JX, Yao CY, Yang JY, Li ZF, He F, Tian YX, Wang H, Xu ZL, Shen YD. Design of Novel Haptens and Development of Monoclonal Antibody-Based Immunoassays for the Simultaneous Detection of Tylosin and Tilmicosin in Milk and Water Samples. Biomolecules. 2019 Nov 23;9(12):770. doi: 10.3390/biom9120770. PMID: 31771142; PMCID: PMC6995535. 17: Lombardi KR, Portillo T, Hassfurther R, Hunter RP. Pharmacokinetics of tilmicosin in beef cattle following intravenous and subcutaneous administration. J Vet Pharmacol Ther. 2011 Dec;34(6):583-7. doi: 10.1111/j.1365-2885.2011.01268.x. Epub 2011 Feb 16. PMID: 21323676. 18: Li B, Gong SY, Zhou XZ, Yang YJ, Li JY, Wei XJ, Cheng FS, Niu JR, Liu XW, Zhang JY. Determination of antibacterial agent tilmicosin in pig plasma by LC/MS/MS and its application to pharmacokinetics. Biomed Chromatogr. 2017 Mar;31(3). doi: 10.1002/bmc.3825. Epub 2016 Sep 28. PMID: 27564248. 19: Luo W, Qin H, Chen D, Wu M, Meng K, Zhang A, Pan Y, Qu W, Xie S. The dose regimen formulation of tilmicosin against Lawsonia intracellularis in pigs by pharmacokinetic-pharmacodynamic (PK-PD) model. Microb Pathog. 2020 Jul 21;147:104389. doi: 10.1016/j.micpath.2020.104389. Epub ahead of print. PMID: 32707311. 20: Blondeau JM, Fitch SD. Mutant prevention and minimum inhibitory concentration drug values for enrofloxacin, ceftiofur, florfenicol, tilmicosin and tulathromycin tested against swine pathogens Actinobacillus pleuropneumoniae, Pasteurella multocida and Streptococcus suis. PLoS One. 2019 Jan 10;14(1):e0210154. doi: 10.1371/journal.pone.0210154. PMID: 30629633; PMCID: PMC6328246.