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MedKoo Cat#: 555828 | Name: LY3325656

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LY3325656 is a GPR142 agonist suitable for clinical testing in human. LY3325656 demonstrated anti-diabetic benefits in pre-clinical studies and ADME/PK properties suitable for human dosing. LY3325656 is the first GPR142 agonist molecule advancing to phase 1 clinic trials for the treatment of Type 2 diabetes.

Chemical Structure

LY3325656
LY3325656
CAS#1998714-25-2 (free base)

Theoretical Analysis

MedKoo Cat#: 555828

Name: LY3325656

CAS#: 1998714-25-2 (free base)

Chemical Formula: C21H23F3N6O2

Exact Mass: 448.1835

Molecular Weight: 448.45

Elemental Analysis: C, 56.25; H, 5.17; F, 12.71; N, 18.74; O, 7.14

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
1998714-25-2 (free base) 1998714-26-3 (tosylate) LY3325656-analog
Synonym
LY3325656; LY-3325656; LY 3325656;
IUPAC/Chemical Name
N-((2S,4R)-2-(5-(1,4-dimethyl-1H-imidazol-5-yl)-4H-1,2,4-triazol-3-yl)tetrahydro-2H-pyran-4-yl)-N-methyl-3-(trifluoromethyl)benzamide
InChi Key
LEKZBCFOSTUBJZ-CVEARBPZSA-N
InChi Code
InChI=1S/C21H23F3N6O2/c1-12-17(29(2)11-25-12)19-26-18(27-28-19)16-10-15(7-8-32-16)30(3)20(31)13-5-4-6-14(9-13)21(22,23)24/h4-6,9,11,15-16H,7-8,10H2,1-3H3,(H,26,27,28)/t15-,16+/m1/s1
SMILES Code
O=C(N([C@H]1C[C@H](OCC1)C2=NN=C(N2)C3=C(C)N=CN3C)C)C4=CC=CC(C(F)(F)F)=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 448.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Liu, Lian Zhu; Ma, Tianwei; Zhou, Jingye; Zhi, Long Hu; Xue, Jun Zhang; Hai, Zhen Zhang; Zeng, Mi; Liu, Jia; Li, Lei; Jiang, Yi; et al Discovery of LY3325656: A GPR142 agonist suitable for clinical testing in human. From Bioorganic & Medicinal Chemistry Letters (2020), 30(5), 126857.