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MedKoo Cat#: 462482 | Name: AMP-PCP disodium
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

AMP-PCP disodium is an ATP analogue and can bind to Hsp90 N-terminal domain. Its binding favors the formation of the active homodimer of Hsp90.

Chemical Structure

AMP-PCP disodium
AMP-PCP disodium
CAS#7414-56-4 (sodium)

Theoretical Analysis

MedKoo Cat#: 462482

Name: AMP-PCP disodium

CAS#: 7414-56-4 (sodium)

Chemical Formula: C11H16N5Na2O12P3

Exact Mass: 548.9804

Molecular Weight: 549.17

Elemental Analysis: C, 24.06; H, 2.94; N, 12.75; Na, 8.37; O, 34.96; P, 16.92

Price and Availability

Size Price Availability Quantity
5mg USD 450.00 2 Weeks
10mg USD 750.00 2 Weeks
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Related CAS #
7414-56-4 (sodium) 3469-78-1 (acid)
Synonym
AMP-PCP disodium; AMP PCP disodium
IUPAC/Chemical Name
A name could not be generated for this structure.
InChi Key
KZCUOVRMGTZINH-LYYWGVPGSA-L
InChi Code
InChI=1S/C11H18N5O12P3.2Na/c12-9-6-10(14-2-13-9)16(3-15-6)11-8(18)7(17)5(27-11)1-26-31(24,25)28-30(22,23)4-29(19,20)21;;/h2-3,5,7-8,11,17-18H,1,4H2,(H,22,23)(H,24,25)(H2,12,13,14)(H2,19,20,21);;/q;2*+1/p-2/t5-,7-,8-,11-;;/m1../s1
SMILES Code
O[C@H]1[C@@H](O[C@H](COP(OP(CP(O)(O[Na])=O)(O[Na])=O)(O)=O)[C@H]1O)N2C3=C(C(N)=NC=N3)N=C2
Appearance
Solid powder
Purity
>97% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 549.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hourani SM, Loizou GD, Cusack NJ. Pharmacological effects of L-AMP-PCP on ATP receptors in smooth muscle. Eur J Pharmacol. 1986 Nov 12;131(1):99-103. doi: 10.1016/0014-2999(86)90521-2. PMID: 3816951. 2: Hourani SM, Welford LA, Cusack NJ. L-AMP-PCP, an ATP receptor agonist in guinea-pig bladder, is inactive on taenia coli. Eur J Pharmacol. 1985 Jan 22;108(2):197-200. doi: 10.1016/0014-2999(85)90726-5. PMID: 2984024. 3: Serysheva II, Schatz M, van Heel M, Chiu W, Hamilton SL. Structure of the skeletal muscle calcium release channel activated with Ca2+ and AMP-PCP. Biophys J. 1999 Oct;77(4):1936-44. doi: 10.1016/S0006-3495(99)77035-9. PMID: 10512814; PMCID: PMC1300475. 4: AlTarabeen M, Al-Balas Q, Albohy A, Müller WEG, Proksch P. Marine-Based Candidates as Potential RSK1 Inhibitors: A Computational Study. Molecules. 2022 Dec 26;28(1):202. doi: 10.3390/molecules28010202. PMID: 36615396; PMCID: PMC9822162. 5: Ruggieri MR, Whitmore KE, Levin RM. Bladder purinergic receptors. J Urol. 1990 Jul;144(1):176-81. doi: 10.1016/s0022-5347(17)39405-3. PMID: 2141655. 6: Tenn CC, Kapur S, Fletcher PJ. Sensitization to amphetamine, but not phencyclidine, disrupts prepulse inhibition and latent inhibition. Psychopharmacology (Berl). 2005 Jul;180(2):366-76. doi: 10.1007/s00213-005-2253-z. Epub 2005 Apr 26. PMID: 15856186. 7: Hübschmann MV, Skladchikova G. The role of ATP in the regulation of NCAM function. Adv Exp Med Biol. 2010;663:81-91. doi: 10.1007/978-1-4419-1170-4_5. PMID: 20017016. 8: Ortiz D, Gossack L, Quast U, Bryan J. Reinterpreting the action of ATP analogs on K(ATP) channels. J Biol Chem. 2013 Jun 28;288(26):18894-902. doi: 10.1074/jbc.M113.476887. Epub 2013 May 12. PMID: 23665564; PMCID: PMC3696665. 9: Ozawa T. Ryanodine-sensitive Ca2+ release mechanism in non-excitable cells (Review). Int J Mol Med. 2001 Jan;7(1):21-5. PMID: 11115603. 10: Pang DC, Briggs FN. Effect of calcium and magnesium on binding of beta, gamma-methylene ATP to sarcoplasmic reticulum. J Biol Chem. 1977 May 25;252(10):3262-6. PMID: 863883. 11: Silva GB, Garvin JL. Extracellular ATP inhibits transport in medullary thick ascending limbs: role of P2X receptors. Am J Physiol Renal Physiol. 2009 Nov;297(5):F1168-73. doi: 10.1152/ajprenal.00325.2009. Epub 2009 Aug 26. PMID: 19710240; PMCID: PMC2781330. 12: Cusack NJ, Hourani SM. Some pharmacological and biochemical interactions of the enantiomers of adenylyl 5'-(beta, gamma-methylene)-diphosphonate with the guinea-pig urinary bladder. Br J Pharmacol. 1984 May;82(1):155-9. doi: 10.1111/j.1476-5381.1984.tb16453.x. PMID: 6547360; PMCID: PMC1987245. 13: Wiegand T, Cadalbert R, Lacabanne D, Timmins J, Terradot L, Böckmann A, Meier BH. The conformational changes coupling ATP hydrolysis and translocation in a bacterial DnaB helicase. Nat Commun. 2019 Jan 3;10(1):31. doi: 10.1038/s41467-018-07968-3. PMID: 30604765; PMCID: PMC6318325. 14: Lacabanne D, Wiegand T, Wili N, Kozlova MI, Cadalbert R, Klose D, Mulkidjanian AY, Meier BH, Böckmann A. ATP Analogues for Structural Investigations: Case Studies of a DnaB Helicase and an ABC Transporter. Molecules. 2020 Nov 12;25(22):5268. doi: 10.3390/molecules25225268. PMID: 33198135; PMCID: PMC7698047. 15: Ember B, LoGrasso P. Mechanistic characterization for c-jun-N-Terminal Kinase 1alpha1. Arch Biochem Biophys. 2008 Sep 15;477(2):324-9. doi: 10.1016/j.abb.2008.06.001. Epub 2008 Jun 5. PMID: 18559253. 16: Liau NPD, Wendorff TJ, Quinn JG, Steffek M, Phung W, Liu P, Tang J, Irudayanathan FJ, Izadi S, Shaw AS, Malek S, Hymowitz SG, Sudhamsu J. Negative regulation of RAF kinase activity by ATP is overcome by 14-3-3-induced dimerization. Nat Struct Mol Biol. 2020 Feb;27(2):134-141. doi: 10.1038/s41594-019-0365-0. Epub 2020 Jan 27. PMID: 31988522. 17: Galun R, Friend WG, Nudelman S. Purinergic reception by culicine mosquitoes. J Comp Physiol A. 1988;163(5):665-70. doi: 10.1007/BF00603850. PMID: 2903919. 18: Thévenod F, Anderie I, Schulz I. Monoclonal antibodies against MDR1 P-glycoprotein inhibit chloride conductance and label a 65-kDa protein in pancreatic zymogen granule membranes. J Biol Chem. 1994 Sep 30;269(39):24410-7. PMID: 7929102. 19: Baruch-Suchodolsky R, Fischer B. Can nucleotides prevent Cu-induced oxidative damage? J Inorg Biochem. 2008 Apr;102(4):862-81. doi: 10.1016/j.jinorgbio.2007.11.023. Epub 2007 Dec 23. PMID: 18255154. 20: Agrawal A, Roué M, Spitzfaden C, Petrella S, Aubry A, Hann M, Bax B, Mayer C. Mycobacterium tuberculosis DNA gyrase ATPase domain structures suggest a dissociative mechanism that explains how ATP hydrolysis is coupled to domain motion. Biochem J. 2013 Dec 1;456(2):263-73. doi: 10.1042/BJ20130538. PMID: 24015710.