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MedKoo Cat#: 597924 | Name: Antiflammin P1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Antiflammin P1 is a nonapeptide fragment of uteroglobin, has no phospholipase A2 inhibitory & anti-inflammatory activity.

Chemical Structure

Antiflammin P1
Antiflammin P1
CAS#118850-71-8

Theoretical Analysis

MedKoo Cat#: 597924

Name: Antiflammin P1

CAS#: 118850-71-8

Chemical Formula: C45H82N12O14S2

Exact Mass: 1078.5515

Molecular Weight: 1079.34

Elemental Analysis: C, 50.08; H, 7.66; N, 15.57; O, 20.75; S, 5.94

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Antiflammin P1; Mqmkkvlds; Antiflamin 1;
IUPAC/Chemical Name
(5S,8S,11S,14S,17S,20S,23S,26S,29S)-5-amino-8-(3-amino-3-oxopropyl)-14,17-bis(4-aminobutyl)-26-(carboxymethyl)-29-(hydroxymethyl)-23-isobutyl-20-isopropyl-11-(2-(methylthio)ethyl)-6,9,12,15,18,21,24,27-octaoxo-2-thia-7,10,13,16,19,22,25,28-octaazatriacontan-30-oic acid
InChi Key
XVZUZGWPOCVGGZ-NETRMLAPSA-N
InChi Code
InChI=1S/C45H82N12O14S2/c1-24(2)21-31(42(67)54-32(22-35(60)61)43(68)56-33(23-58)45(70)71)55-44(69)36(25(3)4)57-41(66)28(12-8-10-18-47)52-38(63)27(11-7-9-17-46)51-40(65)30(16-20-73-6)53-39(64)29(13-14-34(49)59)50-37(62)26(48)15-19-72-5/h24-33,36,58H,7-23,46-48H2,1-6H3,(H2,49,59)(H,50,62)(H,51,65)(H,52,63)(H,53,64)(H,54,67)(H,55,69)(H,56,68)(H,57,66)(H,60,61)(H,70,71)/t26-,27-,28-,29-,30-,31-,32-,33-,36-/m0/s1
SMILES Code
OC[C@@H](C(O)=O)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@H](C(C)C)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CCSC)NC([C@H](CCC(N)=O)NC([C@H](CCSC)N)=O)=O)=O)=O)=O)=O)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,079.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Liu W, Wan J, Han JZ, Li C, Feng DD, Yue SJ, Huang YH, Chen Y, Cheng QM, Li Y, Luo ZQ. Antiflammin-1 attenuates bleomycin-induced pulmonary fibrosis in mice. Respir Res. 2013 Oct 8;14:101. doi: 10.1186/1465-9921-14-101. PubMed PMID: 24098933; PubMed Central PMCID: PMC3856527. 2: Zhang TJ, Han JZ, Liu HJ, Liao XH, Li C, Luo ZQ. [Role of uteroglobin-binding protein in antiflammin-1 promoting IL-10 expression and secretion in RAW264.7 cells induced by endotoxin]. Sheng Li Xue Bao. 2013 Aug 25;65(4):363-9. Chinese. PubMed PMID: 23963067. 3: Mize NK, Buttery M, Ruis N, Leung I, Cormier M, Daddona P. Antiflammin 1 peptide delivered non-invasively by iontophoresis reduces irritant-induced inflammation in vivo. Exp Dermatol. 1997 Aug;6(4):181-5. PubMed PMID: 9293390. 4: Miele L, Cordella-Miele E, Facchiano A, Mukherjee AB. Inhibition of phospholipase A2 by uteroglobin and antiflammin peptides. Adv Exp Med Biol. 1990;279:137-60. Review. PubMed PMID: 2151414. 5: Moreno JJ. Antiflammin peptides in the regulation of inflammatory response. Ann N Y Acad Sci. 2000;923:147-53. Review. PubMed PMID: 11193753. 6: Chan CC, Tuaillon N, Li Q, Shen DF. Therapeutic applications of antiflammin peptides in experimental ocular inflammation. Ann N Y Acad Sci. 2000;923:141-6. Review. PubMed PMID: 11193752. 7: Facchiano A, Cordella-Miele E, Miele L, Mukherjee AB. Inhibition of pancreatic phospholipase A2 activity by uteroglobin and antiflammin peptides: possible mechanism of action. Life Sci. 1991;48(5):453-64. PubMed PMID: 1992287. 8: Zouki C, Ouellet S, Filep JG. The anti-inflammatory peptides, antiflammins, regulate the expression of adhesion molecules on human leukocytes and prevent neutrophil adhesion to endothelial cells. FASEB J. 2000 Mar;14(3):572-80. PubMed PMID: 10698973. 9: Li C, Han J, Li L, Yue S, Li J, Feng D, Liu H, Jiang D, Qin X, Luo Z. Interaction of antiflammin-1 with uteroglobin-binding protein induces phosphorylation of ERK1/2 in NIH 3T3 cells. Peptides. 2007 Nov;28(11):2137-45. Epub 2007 Sep 5. PubMed PMID: 17928103. 10: Han J, Li C, Liu H, Fen D, Hu W, Liu Y, Guan C, Luo ZQ. Inhibition of lipopolysaccharide-mediated rat alveolar macrophage activation in vitro by antiflammin-1. Cell Biol Int. 2008 Sep;32(9):1108-15. doi: 10.1016/j.cellbi.2008.04.023. Epub 2008 May 2. PubMed PMID: 18541446. 11: Märki F, Pfeilschifter J, Rink H, Wiesenberg I. 'Antiflammins': two nonapeptide fragments of uteroglobin and lipocortin I have no phospholipase A2-inhibitory and anti-inflammatory activity. FEBS Lett. 1990 May 21;264(2):171-5. PubMed PMID: 2141575. 12: Marastoni M, Salvadori S, Balboni G, Scaranari V, Santagada V, Romualdi P, Ferri S, Tomatis R. Studies on the anti-phospholipase A2 and anti-inflammatory activities of a synthetic nonapeptide from uteroglobin. Arzneimittelforschung. 1991 Mar;41(3):240-3. PubMed PMID: 1867659. 13: Rivers DB, Rocco MM, Frayha AR. Venom from the ectoparasitic wasp Nasonia vitripennis increases Na+ influx and activates phospholipase C and phospholipase A2 dependent signal transduction pathways in cultured insect cells. Toxicon. 2002 Jan;40(1):9-21. PubMed PMID: 11602274. 14: Miele L, Cordella-Miele E, Mantile G, Peri A, Mukherjee AB. Uteroglobin and uteroglobin-like proteins: the uteroglobin family of proteins. J Endocrinol Invest. 1994 Sep;17(8):679-92. Review. PubMed PMID: 7868811. 15: Lloret S, Moreno JJ. In vitro and in vivo effects of the anti-inflammatory peptides, antiflammins. Biochem Pharmacol. 1992 Oct 6;44(7):1437-41. PubMed PMID: 1417964. 16: Miele L. Antiflammins. Bioactive peptides derived from uteroglobin. Ann N Y Acad Sci. 2000;923:128-40. Review. PubMed PMID: 11193751. 17: Moreno JJ. Effects of antiflammins on transglutaminase and phospholipase A2 activation by transglutaminase. Int Immunopharmacol. 2006 Feb;6(2):300-3. Epub 2005 Aug 31. PubMed PMID: 16399636. 18: Beal JL, Foster SB, Ashby MT. Hypochlorous acid reacts with the N-terminal methionines of proteins to give dehydromethionine, a potential biomarker for neutrophil-induced oxidative stress. Biochemistry. 2009 Nov 24;48(46):11142-8. doi: 10.1021/bi901343d. PubMed PMID: 19839600; PubMed Central PMCID: PMC2796370. 19: Camussi G, Tetta C, Turello E, Baglioni C. Anti-inflammatory peptides inhibit synthesis of platelet-activating factor. Prog Clin Biol Res. 1990;349:69-80. Review. PubMed PMID: 2204939. 20: Camussi G, Tetta C, Baglioni C. Antiflammins inhibit synthesis of platelet-activating factor and intradermal inflammatory reactions. Adv Exp Med Biol. 1990;279:161-72. PubMed PMID: 2096695.