(S)-GNE-140 | CAS#2003234-64-6 | LDHA inhibitor

MedKoo Cat#: 462453 | Name: (S)-GNE-140

Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

(S)-GNE-140 is the less active enantiomer of GNE-140 which can inhibit Lactate dehydrogenase A (LDHA).

Chemical Structure

(S)-GNE-140

CAS#2003234-64-6 (S-isomer)

Theoretical Analysis

MedKoo Cat#: 462453

Name: (S)-GNE-140

CAS#: 2003234-64-6 (S-isomer)

Chemical Formula: C25H23ClN2O3S2

Exact Mass: 498.0839

Molecular Weight: 499.04

Elemental Analysis: C, 60.17; H, 4.65; Cl, 7.10; N, 5.61; O, 9.62; S, 12.85

Price and Availability

Size	Price	Availability	Quantity
10mg	USD 550.00	2 Weeks
25mg	USD 950.00	2 Weeks

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

2003234-63-5 (R-isomer) 1809794-70-4 (racemic) 2003234-64-6 (S-isomer)

Synonym

(S)-GNE-140; (S)-GNE140; (S)-GNE 140

IUPAC/Chemical Name

(S)-3-((2-chlorophenyl)thio)-4-hydroxy-6-(4-morpholinophenyl)-6-(thiophen-3-yl)-5,6-dihydropyridin-2(1H)-one

InChi Key

SUFXXEIVBZJOAP-VWLOTQADSA-N

InChi Code

InChI=1S/C25H23ClN2O3S2/c26-20-3-1-2-4-22(20)33-23-21(29)15-25(27-24(23)30,18-9-14-32-16-18)17-5-7-19(8-6-17)28-10-12-31-13-11-28/h1-9,14,16,29H,10-13,15H2,(H,27,30)/t25-/m0/s1

SMILES Code

O=C1N[C@](C2=CSC=C2)(C3=CC=C(N4CCOCC4)C=C3)CC(O)=C1SC5=CC=CC=C5Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 499.04 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Ma W, Ao S, Zhou J, Li J, Liang X, Yang X, Zhang H, Liu B, Tang W, Liu H, Xiao H, Liang H, Yang X. Methylsulfonylmethane protects against lethal dose MRSA-induced sepsis through promoting M2 macrophage polarization. Mol Immunol. 2022 Jun;146:69-77. doi: 10.1016/j.molimm.2022.04.001. Epub 2022 Apr 20. PMID: 35461144. 2: Nadal-Bufi F, Mason JM, Chan LY, Craik DJ, Kaas Q, Troeira Henriques S. Designed β-Hairpins Inhibit LDH5 Oligomerization and Enzymatic Activity. J Med Chem. 2021 Apr 8;64(7):3767-3779. doi: 10.1021/acs.jmedchem.0c01898. Epub 2021 Mar 25. PMID: 33765386. 3: Mazzio E, Mack N, Badisa RB, Soliman KFA. Triple Isozyme Lactic Acid Dehydrogenase Inhibition in Fully Viable MDA-MB-231 Cells Induces Cytostatic Effects That Are Not Reversed by Exogenous Lactic Acid. Biomolecules. 2021 Nov 24;11(12):1751. doi: 10.3390/biom11121751. PMID: 34944395; PMCID: PMC8698706. 4: Ždralević M, Brand A, Di Ianni L, Dettmer K, Reinders J, Singer K, Peter K, Schnell A, Bruss C, Decking SM, Koehl G, Felipe-Abrio B, Durivault J, Bayer P, Evangelista M, O'Brien T, Oefner PJ, Renner K, Pouysségur J, Kreutz M. Double genetic disruption of lactate dehydrogenases A and B is required to ablate the "Warburg effect" restricting tumor growth to oxidative metabolism. J Biol Chem. 2018 Oct 12;293(41):15947-15961. doi: 10.1074/jbc.RA118.004180. Epub 2018 Aug 29. PMID: 30158244; PMCID: PMC6187639. 5: Varma G, Seth P, Coutinho de Souza P, Callahan C, Pinto J, Vaidya M, Sonzogni O, Sukhatme V, Wulf GM, Grant AK. Visualizing the effects of lactate dehydrogenase (LDH) inhibition and LDH-A genetic ablation in breast and lung cancer with hyperpolarized pyruvate NMR. NMR Biomed. 2021 Aug;34(8):e4560. doi: 10.1002/nbm.4560. Epub 2021 Jun 4. PMID: 34086382; PMCID: PMC8764798.