Synonym
Cycrimine hydrochloride, Cycrimine HCl, Compound 8958; NSC 169452; NSC169452; NSC-169452; Pagitane Hydrochloride
IUPAC/Chemical Name
1-Phenyl-1-cyclopentyl-3-piperidino-1-propanol Hydrochloride
InChi Key
WBCWFMFZMRFRLT-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H29NO.ClH/c21-19(18-11-5-6-12-18,17-9-3-1-4-10-17)13-16-20-14-7-2-8-15-20;/h1,3-4,9-10,18,21H,2,5-8,11-16H2;1H
SMILES Code
OC(C1CCCC1)(C2=CC=CC=C2)CCN3CCCCC3.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
323.90
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Vedasiromoni JR, Ganguly DK. Cycrimine on rat diaphragm. Arch Int Pharmacodyn Ther. 1976 Jan;219(1):64-9. PMID: 1267542.
2: Matejin S, Bukreyeva N, Radosevic D, Sencanski M, Mantlo E, Veljkovic V, Glisic S, Paessler S. In vitro anti-influenza activity of in silico repurposed candidate drug cycrimine. Antivir Ther. 2019;24(8):589-593. doi: 10.3851/IMP3348. PMID: 32108589.
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5: NEW AND nonofficial remedies: cycrimine hydrochloride. J Am Med Assoc. 1955 Feb 5;157(6):510-1. PMID: 13221464.
6: SIGWALD J, PAYOT J. Action thérapeutique symptomatique du chlorhydrate de cycrimine sur les syndromes parkinsoniens [Symptomatic therapeutic effect of cycrimine HCl in parkinsonian syndromes]. Presse Med (1893). 1955 Mar 12;63(19):375-6. French. PMID: 14371520.
7: RENZI AA, MILCH LJ. Effectiveness of procyclidine hydrochloride (kemadrin) and cycrimine hydrochloride (pagitane) in the prevention of airsickness. J Aviat Med. 1958 Aug;29(8):587-9. PMID: 13575361.
8: Sotriffer CA, Liedl KR, Winger RH, Gamper AM, Kroemer RT, Linthicum DS, Rode BM, Varga JM. Heteroligation of a mouse monoclonal IgE antibody (La2) with small molecules, analysed by computer-aided automated docking. Mol Immunol. 1996 Feb;33(2):129-44. doi: 10.1016/0161-5890(95)00124-7. PMID: 8649435.
9: Winger RH, Liedl KR, Sotriffer CA, Gamper AM, Rode BM, Kroemer RT, Varga JM. Prediction of IgE(Lb4)-ligand complex structures by automated docking. J Mol Recognit. 1996 May-Jun;9(3):239-46. doi: 10.1002/(sici)1099-1352(199605)9:3<239::aid-jmr265>3.0.co;2-f. PMID: 8938597.
10: Occelli E, Fontanella L, Testa E. Analoghi biciclici della piperazina XII (1)-Sintesi di 3,8-diazabiciclo [3,2,1] ottani come potenziali antiparkinsoniani [Bicyclic analogs of piperazine. XII. (1) - Synthesis of 3,8-diazabicyclo/3,2,1/octanes as potential antiparkinson agents]. Farmaco Sci. 1977 Apr;32(4):237-47. Italian. PMID: 862878.