MedKoo Cat#: 462433 | Name: YHO-13351
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

YHO-13351 is the water-soluble prodrug of YHO-13177, which is a potent and specific inhibitor of BCRP.

Chemical Structure

YHO-13351
YHO-13351
CAS#1346753-00-1

Theoretical Analysis

MedKoo Cat#: 462433

Name: YHO-13351

CAS#: 1346753-00-1

Chemical Formula: C27H37N3O7S2

Exact Mass: 579.2073

Molecular Weight: 579.73

Elemental Analysis: C, 55.94; H, 6.43; N, 7.25; O, 19.32; S, 11.06

Price and Availability

Size Price Availability Quantity
5mg USD 450.00 2 Weeks
10mg USD 600.00 2 Weeks
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Related CAS #
No Data
Synonym
YHO-13351; YHO13351; YHO 13351
IUPAC/Chemical Name
(Z)-1-(5-(2-cyano-2-(3,4-dimethoxyphenyl)vinyl)thiophen-2-yl)piperidin-4-yl diethylglycinate methanesulfonate
InChi Key
XOEIHKAPFXUACW-QMGGKDRNSA-N
InChi Code
InChI=1S/C26H33N3O4S.CH4O3S/c1-5-28(6-2)18-26(30)33-21-11-13-29(14-12-21)25-10-8-22(34-25)15-20(17-27)19-7-9-23(31-3)24(16-19)32-4;1-5(2,3)4/h7-10,15-16,21H,5-6,11-14,18H2,1-4H3;1H3,(H,2,3,4)/b20-15+;
SMILES Code
N#C/C(C1=CC=C(OC)C(OC)=C1)=C\C2=CC=C(N3CCC(OC(CN(CC)CC)=O)CC3)S2.O=S(C)(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 579.73 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yamazaki R, Nishiyama Y, Furuta T, et al. Novel acrylonitrile derivatives, YHO-13177 and YHO-13351, reverse BCRP/ABCG2-mediated drug resistance in vitro and in vivo. Mol Cancer Ther. 2011;10(7):1252-1263. doi:10.1158/1535-7163.MCT-10-0874