MedKoo Cat#: 574500 | Name: CDDO Imidazolide
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

CDDO Imidazolide is an Nrf2 signaling activator that increases Nrf2 protein expression and enhances Nrf2-dependent cytoprotective gene expression. It inhibits cell growth and induces apoptosis of pancreatic cancer cells in vitro and also reduces acetaminophen-induced liver injury in mice.

Chemical Structure

CDDO Imidazolide
CDDO Imidazolide
CAS# 443104-02-7

Theoretical Analysis

MedKoo Cat#: 574500

Name: CDDO Imidazolide

CAS#: 443104-02-7

Chemical Formula: C34H43N3O3

Exact Mass: 541.3304

Molecular Weight: 541.74

Elemental Analysis: C, 75.38; H, 8.00; N, 7.76; O, 8.86

Price and Availability

Size Price Availability Quantity
10mg USD 350.00 2 Weeks
100mg USD 950.00 3-4 months
200mg USD 1,650.00 3-4 months
500mg USD 3,650.00 3-4 months
1g USD 5,750.00 3-4 months
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Related CAS #
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Synonym
CDDO Im, CDDO-Im; CDDOIm; CDDO Imidazolide; CDDO-Imidazolide; RTA 403; RTA403; RTA-403
IUPAC/Chemical Name
1-(2-Cyano-3,12,28-trioxooleana-1,9(11)-dien-28-yl)-1H-imidazole
InChi Key
ITFBYYCNYVFPKD-FMIDTUQUSA-N
InChi Code
InChI=1S/C34H43N3O3/c1-29(2)10-12-34(28(40)37-15-14-36-20-37)13-11-33(7)26(22(34)18-29)23(38)16-25-31(5)17-21(19-35)27(39)30(3,4)24(31)8-9-32(25,33)6/h14-17,20,22,24,26H,8-13,18H2,1-7H3/t22-,24-,26-,31-,32+,33+,34-/m0/s1
SMILES Code
O=C1C(C#N)=C[C@@]2(C)[C@](CC[C@]([C@@]4(C)[C@]([H])3[C@@]5([H])[C@@](CCC(C)(C)C5)([C@](N6C=NC=C6)=O)CC4)(C)C2=CC3=O)([H])C(C)1C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 541.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Reisman et al (2009) CDDO-Im protects from acetaminophen hepatotoxicity through induction of Nrf2-dependent genes. Toxicol.Appl.Pharmacol. 236 109 PMID: 19371629 2. Samudio et al (2005) 2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer. J.Biol.Chem. 280 36273 PMID: 16118208 3. Aleksunes et al (2010) Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity. J.Pharmacol.Exp.Ther. 335 2 PMID: 20605904