MedKoo Cat#: 558682 | Name: CDg16

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CDg16 is a probe specific for activated macrophages, for visualizing inflammatory atherosclerotic plaques in vivo, and for targeting the orphan transporter Slc18b1/SLC18B1. CDg16 can detect M1 macrophages regardless of tissue types. CDg16 stains Mφ* selectively and successfully visualized the active inflammatory sites of atherosclerosis in animal model, overcoming the major hurdle for the targeted imaging of inflammation.

Chemical Structure

CDg16
CAS#NONE

Theoretical Analysis

MedKoo Cat#: 558682

Name: CDg16

CAS#: NONE

Chemical Formula: C27H23N5O3

Exact Mass: 465.1801

Molecular Weight: 465.51

Elemental Analysis: C, 69.66; H, 4.98; N, 15.04; O, 10.31

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CDg-16; CDg 16; CDg16
IUPAC/Chemical Name
N-(2-((6-Aminoacridin-3-yl)amino)-2-oxoethyl)-N-(4-methylbenzyl)isoxazole-5-carboxamide
InChi Key
AWIKXLPAZBIGTR-UHFFFAOYSA-N
InChi Code
InChI=1S/C27H23N5O3/c1-17-2-4-18(5-3-17)15-32(27(34)25-10-11-29-35-25)16-26(33)30-22-9-7-20-12-19-6-8-21(28)13-23(19)31-24(20)14-22/h2-14H,15-16,28H2,1H3,(H,30,33)
SMILES Code
O=C(C1=CC=NO1)N(CC(NC2=CC3=NC4=CC(N)=CC=C4C=C3C=C2)=O)CC5=CC=C(C)C=C5
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 465.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Park SJ, Kim B, Choi S, Balasubramaniam S, Lee SC, Lee JY, Kim HS, Kim JY, Kim JJ, Lee YA, Kang NY, Kim JS, Chang YT. Imaging inflammation using an activated macrophage probe with Slc18b1 as the activation-selective gating target. Nat Commun. 2019 Mar 7;10(1):1111. doi: 10.1038/s41467-019-08990-9. PubMed PMID: 30846702; PubMed Central PMCID: PMC6405920.