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MedKoo Cat#: 462393 | Name: DB1976

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DB1976 is a selenophene analog of DB270 and a potent and cell-permeable fully efficacious transcription factor PU.1 inhibitor. DB1976 potently inhibits PU.1 binding and strongly inhibits the PU.1/DNA complex in vitro. DB1976 has apoptosis-inducing effect.

Chemical Structure

DB1976
DB1976
CAS#1557397-51-9 (free base)

Theoretical Analysis

MedKoo Cat#: 462393

Name: DB1976

CAS#: 1557397-51-9 (free base)

Chemical Formula: C20H16N8Se

Exact Mass: 448.0663

Molecular Weight: 447.36

Elemental Analysis: C, 53.70; H, 3.61; N, 25.05; Se, 17.65

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
2369663-93-2 (HCl) 1557397-51-9 (free base)
Synonym
DB1976 ; DB-1976; DB 1976; Y5U
IUPAC/Chemical Name
2,2'-(selenophene-2,5-diyl)bis(1H-benzo[d]imidazole-6-carboximidamide)
InChi Key
NXECULIQZLOKFU-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H16N8Se/c21-17(22)9-1-3-11-13(7-9)27-19(25-11)15-5-6-16(29-15)20-26-12-4-2-10(18(23)24)8-14(12)28-20/h1-8H,(H3,21,22)(H3,23,24)(H,25,27)(H,26,28)
SMILES Code
N=C(C1=CC=C2N=C(C3=CC=C(C4=NC5=CC=C(C(N)=N)C=C5N4)[Se]3)NC2=C1)N
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 447.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Munde M, Wang S, Kumar A, et al. Structure-dependent inhibition of the ETS-family transcription factor PU.1 by novel heterocyclic diamidines. Nucleic Acids Res. 2014;42(2):1379-1390. doi:10.1093/nar/gkt955 2: Stephens DC, Kim HM, Kumar A, Farahat AA, Boykin DW, Poon GM. Pharmacologic efficacy of PU.1 inhibition by heterocyclic dications: a mechanistic analysis. Nucleic Acids Res. 2016;44(9):4005-4013. doi:10.1093/nar/gkw229 3: Antony-Debré I, Paul A, Leite J, et al. Pharmacological inhibition of the transcription factor PU.1 in leukemia. J Clin Invest. 2017;127(12):4297-4313. doi:10.1172/JCI92504