BR351 | CAS#960113-85-3 | MMP inhibitor

MedKoo Cat#: 462291 | Name: BR351

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BR351 is a brain penetrant MMP inhibitor for MMP2, MMP8, MMP9 and MMP13, respectively.

Chemical Structure

BR351

CAS#960113-85-3

Theoretical Analysis

MedKoo Cat#: 462291

Name: BR351

CAS#: 960113-85-3

Chemical Formula: C20H25FN2O5S

Exact Mass: 424.1468

Molecular Weight: 424.49

Elemental Analysis: C, 56.59; H, 5.94; F, 4.48; N, 6.60; O, 18.85; S, 7.55

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

BR351; BR-351; BR 351

IUPAC/Chemical Name

(R)-2-((N-benzyl-4-(2-fluoroethoxy)phenyl)sulfonamido)-N-hydroxy-3-methylbutanamide

InChi Key

NSDMBIOAMTZMED-LJQANCHMSA-N

InChi Code

InChI=1S/C20H25FN2O5S/c1-15(2)19(20(24)22-25)23(14-16-6-4-3-5-7-16)29(26,27)18-10-8-17(9-11-18)28-13-12-21/h3-11,15,19,25H,12-14H2,1-2H3,(H,22,24)/t19-/m1/s1

SMILES Code

CC(C)[C@@H](N(S(=O)(C1=CC=C(OCCF)C=C1)=O)CC2=CC=CC=C2)C(NO)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 424.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Wagner S, Breyholz HJ, Law MP, et al. Novel fluorinated derivatives of the broad-spectrum MMP inhibitors N-hydroxy-2(R)-[[(4-methoxyphenyl)sulfonyl](benzyl)- and (3-picolyl)-amino]-3-methyl-butanamide as potential tools for the molecular imaging of activated MMPs with PET. J Med Chem. 2007;50(23):5752-5764. doi:10.1021/jm0708533