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MedKoo Cat#: 112018 | Name: Fluazinam
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fluazinam is a fungicide. It inhibits mycelial growth of 35 plant pathogenic fungi, including S. sclerotiorum, P. infestans, C. rolfsii, B. cinerea, and Fusarium (EC50s = <0.1-42.1 ppm). Fluazinam (0.56 kg/ha) reduces the incidence of Sclerotinia blight in peanut fields. It decreases the incidence of leaf drop in lettuce fields experimentally infected with S. minor or S. sclerotiorum when applied at a concentration of 561 g AI/ha. Formulations containing fluazinam have been used as fungicides in agriculture.

Chemical Structure

Fluazinam
Fluazinam
CAS#79622-59-6

Theoretical Analysis

MedKoo Cat#: 112018

Name: Fluazinam

CAS#: 79622-59-6

Chemical Formula: C13H4Cl2F6N4O4

Exact Mass: 463.9514

Molecular Weight: 465.09

Elemental Analysis: C, 33.57; H, 0.87; Cl, 15.24; F, 24.51; N, 12.05; O, 13.76

Price and Availability

Size Price Availability Quantity
1g USD 450.00 2 Weeks
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Related CAS #
No Data
Synonym
Fluazinam; Frowncide; ASC 66825; ASC66825; ASC-66825; ASC 67178; ASC67178; ASC-67178; IKF 1216; IKF1216; IKF-1216;
IUPAC/Chemical Name
3-chloro-N-(3-chloro-2,6-dinitro-4-(trifluoromethyl)phenyl)-5-(trifluoromethyl)pyridin-2-amine
InChi Key
UZCGKGPEKUCDTF-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H4Cl2F6N4O4/c14-6-1-4(12(16,17)18)3-22-11(6)23-9-7(24(26)27)2-5(13(19,20)21)8(15)10(9)25(28)29/h1-3H,(H,22,23)
SMILES Code
ClC1=C(C(F)(F)F)C=C([N+]([O-])=O)C(NC2=NC=C(C(F)(F)F)C=C2Cl)=C1[N+]([O-])=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
DMF 25.0 53.75
DMSO 25.0 53.75
Ethanol 15.0 32.25
PBS (pH: 7.2) 0.3 0.54
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 465.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Cheng X, Dai T, Hu Z, Cui T, Wang W, Han P, Hu M, Hao J, Liu P, Liu X. Cytochrome P450 and Glutathione S-Transferase Confer Metabolic Resistance to SYP-14288 and Multi-Drug Resistance in Rhizoctonia solani. Front Microbiol. 2022 Mar 21;13:806339. doi: 10.3389/fmicb.2022.806339. PMID: 35387083; PMCID: PMC8977892. 2: Malandrakis AA, Kavroulakis N, Chrysikopoulos CV. Zinc nanoparticles: Mode of action and efficacy against boscalid-resistant Alternaria alternata isolates. Sci Total Environ. 2022 Jul 10;829:154638. doi: 10.1016/j.scitotenv.2022.154638. Epub 2022 Mar 18. PMID: 35314223. 3: Suguinoshita Rebello C, Baggio JS, Forcelini BB, Peres NA. Sensitivity of Colletotrichum acutatum species complex from strawberry to fungicide alternatives to quinone-outside inhibitors. Plant Dis. 2022 Mar 12. doi: 10.1094/PDIS-09-21-1934-RE. Epub ahead of print. PMID: 35285270. 4: Vieira RF, Lima RC, Teixeira PH, Paula Júnior TJ, Carneiro JES, Possamai F, Braun H, Lima MS. Managing white mold on common bean with type III growth habit by integrating partial resistance, plant density and fungicide. Plant Dis. 2022 Feb 27. doi: 10.1094/PDIS-11-21-2414-RE. Epub ahead of print. PMID: 35224984. 5: Dai T, Wang Z, Cheng X, Gao H, Liang L, Liu P, Liu X. Uncoupler SYP-14288 inducing multidrug resistance of Phytophthora capsici through overexpression of cytochrome P450 monooxygenases and P-glycoprotein. Pest Manag Sci. 2022 Jun;78(6):2240-2249. doi: 10.1002/ps.6845. Epub 2022 Mar 14. PMID: 35191608. 6: Noh HH, Jo SH, Shin HW, Kim DJ, Ham YJ, Kim JY, Kim DB, Kwon HY, Kyung KS. Dissipation and Residue Pattern of Dinotefuran, Fluazinam, Indoxacarb, and Thiacloprid in Fresh and Processed Persimmon Using LC-MS/MS. Foods. 2022 Jan 31;11(3):416. doi: 10.3390/foods11030416. PMID: 35159566; PMCID: PMC8834564. 7: Saifullah S, Margus A, Kankare M, Lindström L. Repeated exposure of fluazinam fungicides affects gene expression profiles yet carries no costs on a nontarget pest. Insect Sci. 2022 Feb 10. doi: 10.1111/1744-7917.13013. Epub ahead of print. PMID: 35143114. 8: Iwaniuk P, Lozowicka B. Biochemical compounds and stress markers in lettuce upon exposure to pathogenic Botrytis cinerea and fungicides inhibiting oxidative phosphorylation. Planta. 2022 Feb 10;255(3):61. doi: 10.1007/s00425-022-03838-x. PMID: 35141769; PMCID: PMC8828598. 9: Zhou F, Cui YX, Wang BL, Zhou YD, Li SW, Zhang YT, Zhang K, Chen ZY, Hu HY, Li CW. Baseline sensitivity and potential resistance mechanisms for Fusarium pseudograminearum to fludioxonil. Plant Dis. 2022 Jan 31. doi: 10.1094/PDIS-12-21-2626-RE. Epub ahead of print. PMID: 35100030. 10: Magagula P, Taylor N, Swart V, van den Berg N. Efficacy of Potential Control Agents Against Rosellinia necatrix and Their Physiological Impact on Avocado. Plant Dis. 2021 Nov;105(11):3385-3396. doi: 10.1094/PDIS-08-20-1751-RE. Epub 2021 Nov 7. PMID: 34743539. 11: Shirley AM, Vallad GE, Dufault N, Raid R, Quesada-Ocampo L. Duration of Downy Mildew Control Achieved with Fungicides on Cucumber Under Florida Field Conditions. Plant Dis. 2022 Apr;106(4):1167-1174. doi: 10.1094/PDIS-03-21-0507-RE. Epub 2022 Mar 23. PMID: 34546773. 12: da Silva Lehner M, Alves KS, Del Ponte EM, Pethybridge SJ. Comparing the Fungicide Sensitivity of Sclerotinia sclerotiorum Using Mycelial Growth and Ascospore Germination Assays. Plant Dis. 2022 Feb;106(2):360-363. doi: 10.1094/PDIS-06-21-1234-SC. Epub 2022 Feb 9. PMID: 34524868. 13: Rubert J, Dornelles SHB, Nunes UR, Pedrollo NT, Peripolli M, Cassol JC. Treatment with insecticide and fungicide on the physiological quality of lentil seeds. Braz J Biol. 2021 Aug 27;83:e246670. doi: 10.1590/1519-6984.246670. PMID: 34468520. 14: Martin PL, Krawczyk T, Pierce K, Thomas C, Khodadadi F, Aćimović SG, Peter KA. Fungicide Sensitivity of Colletotrichum Species Causing Bitter Rot of Apple in the Mid-Atlantic U.S.A. Plant Dis. 2022 Feb;106(2):549-563. doi: 10.1094/PDIS-06-21-1142-RE. Epub 2022 Feb 8. PMID: 34353127. 15: Zhou F, Cui YX, Ma YH, Wang JY, Hu HY, Li SW, Zhang FL, Li CW. Investigating the Potential Mechanism of Pydiflumetofen Resistance in Sclerotinia sclerotiorum. Plant Dis. 2021 Nov;105(11):3580-3585. doi: 10.1094/PDIS-03-21-0455-RE. Epub 2021 Nov 18. PMID: 33934629. 16: Malandrakis AA, Kavroulakis N, Chrysikopoulos CV. Copper nanoparticles against benzimidazole-resistant Monilinia fructicola field isolates. Pestic Biochem Physiol. 2021 Mar;173:104796. doi: 10.1016/j.pestbp.2021.104796. Epub 2021 Feb 5. PMID: 33771267. 17: Dos Santos PRR, Alves MVG, Dos Santos GR. Botanical and chemical fungicides in the treatment of commercial seeds of Brachiaria brizantha and Panicum maximum. J Basic Microbiol. 2021 May;61(5):459-471. doi: 10.1002/jobm.202000588. Epub 2021 Mar 8. PMID: 33682166. 18: Souders CL 2nd, Wei C, Schmidt JT, Da Fonte DF, Xing L, Trudeau VL, Martyniuk CJ. Mitochondria of teleost radial glia: A novel target of neuroendocrine disruption by environmental chemicals? Comp Biochem Physiol C Toxicol Pharmacol. 2021 May;243:108995. doi: 10.1016/j.cbpc.2021.108995. Epub 2021 Feb 2. PMID: 33545344. 19: Liu Q, Liu P, Xu Y, Wang B, Liu P, Hao J, Liu X. Encapsulation of fluazinam to extend efficacy duration in controlling Botrytis cinerea on cucumber. Pest Manag Sci. 2021 Jun;77(6):2836-2842. doi: 10.1002/ps.6318. Epub 2021 Feb 17. PMID: 33538400. 20: Shang Y, Wang Y, Deng J, Liu X, Fang Y, Rao Q, Wu H. Comparative Transcriptome Analysis Reveals the Mechanism Related to Fluazinam Stress of Panonychus citri (Acarina: Tetranychidae). Insects. 2020 Oct 26;11(11):730. doi: 10.3390/insects11110730. PMID: 33114558; PMCID: PMC7692568.