MedKoo Cat#: 462264 | Name: CDK5 inhibitor 20-223
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

CDK5 inhibitor 20-223 is a potent CDK2 and CDK5 inhibitor with IC50s of 6.0 and 8.8 nM, respectively. CDK5 inhibitor 20-223 is an effective anti-colorectal cancer (CRC) agent.

Chemical Structure

CDK5 inhibitor 20-223
CAS#865317-30-2

Theoretical Analysis

MedKoo Cat#: 462264

Name: CDK5 inhibitor 20-223

CAS#: 865317-30-2

Chemical Formula: C19H19N3O

Exact Mass: 305.1528

Molecular Weight: 305.38

Elemental Analysis: C, 74.73; H, 6.27; N, 13.76; O, 5.24

Price and Availability

Size Price Availability Quantity
5mg USD 400.00 2 Weeks
10mg USD 750.00 2 Weeks
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Related CAS #
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Synonym
CDK5 inhibitor 20-223; CDK5-IN-20-223
IUPAC/Chemical Name
N-(5-cyclobutyl-1H-pyrazol-3-yl)-2-(naphthalen-2-yl)acetamide
InChi Key
AGVIDDQHAQSPIZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H19N3O/c23-19(20-18-12-17(21-22-18)15-6-3-7-15)11-13-8-9-14-4-1-2-5-16(14)10-13/h1-2,4-5,8-10,12,15H,3,6-7,11H2,(H2,20,21,22,23)
SMILES Code
O=C(NC1=NNC(C2CCC2)=C1)CC3=CC=C4C(C=CC=C4)=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 305.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Robb CM, Kour S, Contreras JI, et al. Characterization of CDK(5) inhibitor, 20-223 (aka CP668863) for colorectal cancer therapy. Oncotarget. 2017;9(4):5216-5232. Published 2017 Dec 28. doi:10.18632/oncotarget.23749