MedKoo Cat#: 574452 | Name: BMS-181174

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BMS-181174 is an analog of Mitomycin C with activity against a range of tumour cell lines and xenografts, including MMC-resistant tumours. Phase I clinical trials from Bristol-Myers Squibb demonstrated that BMS-181174 has a similar toxicity profile to mitomycin.

Chemical Structure

BMS-181174
BMS-181174
CAS#95056-36-3

Theoretical Analysis

MedKoo Cat#: 574452

Name: BMS-181174

CAS#: 95056-36-3

Chemical Formula: C23H25N5O7S2

Exact Mass: 547.1195

Molecular Weight: 547.60

Elemental Analysis: C, 50.45; H, 4.60; N, 12.79; O, 20.45; S, 11.71

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Synonym
BMS-181174; BMS181174; BMS 181174; BMY 25067; BMY25067; BMY-25067
IUPAC/Chemical Name
(1aS,8R,8aR,8bS)-8-[[(Aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-6-[[2-[(4-nitrophenyl)dithio]ethyl]amino]-azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione
InChi Key
ZNDJOCJUBZZAMN-ZRQBBWCYSA-N
InChi Code
InChI=1S/C23H25N5O7S2/c1-11-17(25-7-8-36-37-13-5-3-12(4-6-13)28(32)33)20(30)16-14(10-35-22(24)31)23(34-2)21-15(26-21)9-27(23)18(16)19(11)29/h3-6,14-15,21,25-26H,7-10H2,1-2H3,(H2,24,31)/t14-,15-,21-,23+/m0/s1
SMILES Code
O=C1C(C)=C(NCCSSC2=CC=C([N+]([O-])=O)C=C2)C(C3=C1N4[C@@]([C@](N5)([H])[C@]5([H])C4)(OC)[C@H]3COC(N)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 547.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL