Synonym
Difetarsone; Difetarsonum; Diphetarson; RP 4763; RP-4763; RP4763; Benarsal;
IUPAC/Chemical Name
((ethane-1,2-diylbis(azanediyl))bis(4,1-phenylene))diarsonic acid
InChi Key
YQVALJGIKVYRNI-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H18As2N2O6/c19-15(20,21)11-1-5-13(6-2-11)17-9-10-18-14-7-3-12(4-8-14)16(22,23)24/h1-8,17-18H,9-10H2,(H2,19,20,21)(H2,22,23,24)
SMILES Code
O=[As](C1=CC=C(NCCNC2=CC=C([As](O)(O)=O)C=C2)C=C1)(O)O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Biological target:
Difetarsone is an antiprotozoal agent.
|
Solvent |
mg/mL |
mM |
comments |
| Solubility |
| DMSO |
0.0 |
0.00 |
|
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
460.14
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Labadie H, Dyan S, Novello P, Pouteau M, Licht H. Hépatite à la difétarsone. Une deuxième observation [Diphetarsone-induced hepatitis. A second case]. Presse Med. 1992 Jun 6;21(21):996. French. PMID: 1386461.
2: Vetter D, Arpin MP, Doffoël M, Charrault A, Biour M, Bockel R. Hépatitie prolongée après la prise de difétarsone [Prolonged hepatitis after ingestion of diphetarsone]. Gastroenterol Clin Biol. 1988 Feb;12(2):173-4. French. PMID: 3366319.
3: Leary PM, Jones C, Douglas F, Boyd ST. Difetarsone in outpatient treatment of Trichuris trichiura infestation. Arch Dis Child. 1974 Jun;49(6):486-8. doi: 10.1136/adc.49.6.486. PMID: 4851370; PMCID: PMC1648795.
4: Boyce JM, Fitzgerald TC, Gregg R. Difetarsone ('Bemarsal') and other anthelminthic drugs in the treatment of Trichuris trichiura (whipworm) infestation in a subnormality hospital. Br J Psychiatry. 1974 Feb;124(579):160-5. doi: 10.1192/bjp.124.2.160. PMID: 4825661.
5: Vandepitte J, Gatti F, Krubwa F, Thienpont D. Letter: Difetarsone in the treatment of Trichuris trichiura. S Afr Med J. 1973 Nov 24;47(46):2205. PMID: 4760912.
6: Leary PM, Elsworth M, Maytham D, Jones C, Douglas F, Boyd S. Difetarsone in the treatment of Trichuris trichiura. S Afr Med J. 1973 Aug 11;47(31):1389. PMID: 4578732.
7: Rubidge CJ, O'Dowd PB, Powell SJ. Difetarsone in the treatment of Trichuris trichiura infections. S Afr Med J. 1973 Jun 16;47(23):991-2. PMID: 4714286.
8: Vandepitte J, Thienpont D. Trichuris infestations and difetarsone. Br Med J. 1972 Dec 2;4(5839):549. doi: 10.1136/bmj.4.5839.549-b. PMID: 4642803; PMCID: PMC1788733.
9: Lynch DM, Green EA, McFadzean JA, Pugh IM. Trichuris trichiura infestations in the United Kingdom and treatment with difetarsone. Br Med J. 1972 Oct 14;4(5832):73-6. doi: 10.1136/bmj.4.5832.73. PMID: 5077469; PMCID: PMC1786249.
