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MedKoo Cat#: 585043 | Name: ML 67-33
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

ML 67-33 is a K2P potassium channel activator that increases channel currents by activating core gating apparatus of channels.

Chemical Structure

ML 67-33
ML 67-33
CAS#1443290-89-8

Theoretical Analysis

MedKoo Cat#: 585043

Name: ML 67-33

CAS#: 1443290-89-8

Chemical Formula: C18H17Cl2N5

Exact Mass: 373.0861

Molecular Weight: 374.27

Elemental Analysis: C, 57.77; H, 4.58; Cl, 18.94; N, 18.71

Price and Availability

Size Price Availability Quantity
50mg USD 550.00 2 weeks
100mg USD 950.00 2 weeks
1g USD 4,450.00 2 Weeks
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Related CAS #
No Data
Synonym
ML 67-33; ML 67 33; ML 6733
IUPAC/Chemical Name
2,7-Dichloro-9,10-dihydro-9,9-dimethyl-10-[2-(2H-tetrazol-5-yl)ethyl]acridine
InChi Key
GQPMJOXQJUGJPG-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H17Cl2N5/c1-18(2)13-9-11(19)3-5-15(13)25(8-7-17-21-23-24-22-17)16-6-4-12(20)10-14(16)18/h3-6,9-10H,7-8H2,1-2H3,(H,21,22,23,24)
SMILES Code
CC1(C)C2=C(C=CC(Cl)=C2)N(CCC3=NNN=N3)C4=CC=C(Cl)C=C14
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
ML67-33 is a selective activator of temperature- and mechano-sensitive K2P channels.
In vitro activity:
By combining biophysical, structure-activity, and mechanistic analysis, this study developed a dihydroacridine analogue, ML67-33, that acts as a low micromolar, selective activator of temperature- and mechano-sensitive K2P channels. Biophysical studies show that ML67-33 reversibly increases channel currents by activating the extracellular selectivity filter-based C-type gate that forms the core gating apparatus on which a variety of diverse modulatory inputs converge. Reference: CS Chem Biol. 2013 Aug 16;8(8):1841-51. https://pubmed.ncbi.nlm.nih.gov/23738709/
In vivo activity:
TBD
Solvent mg/mL mM comments
Solubility
DMSO 68.7 183.60
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 374.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
Bagriantsev SN, Ang KH, Gallardo-Godoy A, Clark KA, Arkin MR, Renslo AR, Minor DL Jr. A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K2P channels. ACS Chem Biol. 2013 Aug 16;8(8):1841-51. doi: 10.1021/cb400289x. Epub 2013 Jun 17. PMID: 23738709; PMCID: PMC3747594.
In vitro protocol:
Bagriantsev SN, Ang KH, Gallardo-Godoy A, Clark KA, Arkin MR, Renslo AR, Minor DL Jr. A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K2P channels. ACS Chem Biol. 2013 Aug 16;8(8):1841-51. doi: 10.1021/cb400289x. Epub 2013 Jun 17. PMID: 23738709; PMCID: PMC3747594.
In vivo protocol:
TBD
Bagriantsev et al (2013) A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K2P channels. ACS Chem.Biol. 8 1841 PMID: 23738709 Pope et al (2018) Protein and chemical determinants of BL-1249 action and selectivity for K2P channels. ACS Chem.Neurosci. 9 3153 PMID: 30089357